期刊文献+

Akirin基因研究进展 被引量:1

Research Progress of Akirin Gene
原文传递
导出
摘要 Akirin是近来发现的在骨骼肌生长发育和免疫反应中具有重要作用的基因。简要综述了akirin基因与免疫反应、骨骼肌发育和再生、myostatin基因和NF-κB因子的关系,同时分析了禽类akirin2基因的研究进展,最后对akirin基因的应用前景也进行了简单探讨,以期为akirin基因在医学和畜牧业中的深入研究和应用提供参考。 Akirin is a recently discovered gene,which plays important roles in skeletal muscle development and immune response.The relationships between akirin gene and immune response,development and regeneration of skeletal muscle,myostatin gene and NF-κB factor are mainly summarized,and the research progress of poultry akirin2 gene.Additionally,the using prospects of akirin gene were also discussed briefly.is reviewed provide References for further studying and use of akirin gene in medical and animal husbandry fields are provided.
出处 《中国生物工程杂志》 CAS CSCD 北大核心 2012年第3期106-109,共4页 China Biotechnology
基金 黑龙江省自然科学基金(C201135) 黑龙江省教育厅科学技术研究项目(12511140) 黑龙江省高校科技创新团队研究计划资助项目
关键词 Akirin基因 免疫 骨骼肌 MYOSTATIN NF-ΚB Akirin gene Immunity Skeletal muscle Myostatin NF-κB
  • 相关文献

参考文献24

  • 1Goto A,Matsushita K,Gesellchen V,et al.Akirins,highlyconserved nuclear proteins,required for NF-κB dependent geneexpression in Drosophila and mice.Nat Immunol,2008,9(1):97-104.
  • 2Moreno-Cid J A,Jiménez M,Cornelie S,et al.Characterizationof Aedes albopictus akirin for the control of mosquito and sand flyinfestations.Vaccine,2010,29(1):77-82.
  • 3Marshall A,Salerno M S,Thomas M,et al.Mighty is a novelpromyogenic factor in skeletal myogenesis.Exp Cell Res,2008,314(5):1013-1029.
  • 4Salerno M S,Dyer K,Bracegirdle J,et al.Akirin1(Mighty),anovel promyogenic factor regulates muscle regeneration and cellchemotaxis.Exp Cell Res,2009,315(12):2012-2021.
  • 5McPherron A C,Lee S J.Double muscling in cattle due tomutations in the Myostatin gene.Proc Natl Acad Sci USA,1997,94(23):12457-12461.
  • 6Sazanov A,Ewald D,Buitkamp J,et al.A molecular marker forthe chicken Myostatin gene(GDF8)maps to 7p11.Anim Genet,1999,30(5):388-389.
  • 7Kambadur R,Sharma M,Smith T P,et al.Mutations inMyostatin(GDF8)in double-muscled Belgian Blue andPiedmontese cattle.Genome Res,1997,7(9):910-916.
  • 8Grobet L,Martin L J,Poncelet D,et al.A deletion in the bovineMyostatin gene causes the double-muscled phenotype in cattle.Nat Genet,1997,17(1):71-74.
  • 9Lenardo M J,Baltimore D.NF-kappa B:a pleiotropic mediator ofinducible and tissue-specific gene control.Cell,1989,58(2):227-229.
  • 10Hayden M S,Ghosh S.Signaling to NF-kappaB.Genes Dev,2004,18(18):2195-2224.

二级参考文献38

  • 1朱桂军,于占彪,李淑瑾,刘俊峰,胡振杰.二烯丙基三硫对脂多糖诱导小鼠肺泡巨噬细胞株MH-S细胞因子生成的影响[J].中国急救医学,2006,26(10):680-682. 被引量:5
  • 2赵清石,江新梅,鞠浩.调节骨骼肌再生过程的分泌因子[J].中国老年学杂志,2007,27(6):598-599. 被引量:2
  • 3张江丽.胚胎发育中骨骼肌组织的形成及调控[J].安徽农业科学,2007,35(21):6447-6448. 被引量:9
  • 4Marshall A,Salerno M S,Thomas M,et al. Mighty is a novel promyogenic factor in skeletal myogenesis [J]. Science Direct Experimental Cell Research,2008,314(5):1013-1029.
  • 5Macqueen D J,Johnston I A. Evolution of the multifaceted eukaryotic akirin gene family [J]. BMC ,Evolutionary Biology, 2009,9(34) : 1-20.
  • 6Goto A,Matsushita K, Gesellchen conserved nuclear proteins required V,et al. Akirins are highly for NF-kappaB-dependent gene expression in drosophila and mice [J].Nat Immunol,2008,9 (1) :97-104.
  • 7Plomgaard P,Penkowa M,Pedersen B K. Fiber type specific expression of TNF-alpha,IL-6 and IL-18 in human skeletal muscles [J]. Exerc Immunol Rev,2005,11 : 53-56,57-61.
  • 8Hvak K J,Schmittgen T D. Analysis ofrelative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C ( T ) )Method [J ]. Methods, 2001,25 (4) : 402-408.
  • 9Shi H,Schefl]er J M,Pleimer J M,et al. Modulation of skeletal muscle fiber type by mitogen-activated protein kinase signaling[J]. The FASEB Journal,2008,22(8) :2990-2999.
  • 10BEUTLER B, MORESCO E M. Akirins versus in- fection [J]. Nat Immunol, 2008, 9(1) : 7-9.

共引文献8

同被引文献9

引证文献1

二级引证文献3

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部