VEGF基因多态性与内异症发病风险相关性的荟萃分析

Vascular endothelial growth factor gene polymorphisms and the risk of endometriosis：a systematic review

目的评价血管内皮生长因子（VEGF）多个基因位点的单核苷酸多态性（SNP）与内异症发病风险的相关性。方法检索Medline数据库、Cochrane图书馆数据库、中国知网（CNKI）、中国生物医学文献数据库（CBM）、万方数据库、西文生物医学期刊文献数据库（FMJS）中有关VEGF基因多态性与内异症发病风险的病例对照研究。对纳入的研究进行质量评价，并采用RevMan5．0软件进行荟萃分析。结果最终有9篇文献纳入本研究，对VEGF基因的3个位点-460C／T、＋405C／G、＋936C／T进行评价，累计病例组（为内异症患者）1610例，对照组（为非内异症患者）1643例。荟萃分析结果显示，VEGF基因-460C／T位点的CC、CT、TT基因型频率及C、T等位基因频率在病例组与对照组间比较，差异均元统计学意义（P〉0．05）。VEGF基因＋405C／G位点的CC基因型频率在两组问比较，差异有统计学意义（P=0．009，OR=1．45，95％CI为1．10—1．91）；C等位基因频率在两组间比较，差异有统计学意义（P=0．020，OR=1．19，95％CI为1．03～1．38）。VEGF基因＋936C／T位点CC基因型频率在两组间比较，差异有统计学意义（P=0．050，OR=0．81，95％CI为0．66—1．00）；T等位基因频率在两组间比较，差异有统计学意义（P=0．040，OR=1．20，95％CI为1．01—1．43）。结论VEGF基因＋405C／G、＋936C／T位点的SNP与内异症发病相关，其中携带VEGF基因＋405C／G位点的C等位基因或＋936C／T位点的T等位基因者可能增加罹患内异症的风险。

Objective To analyze the potential association between the single ucleotide polymorphisms（SNP） of the vascular endothelial growth factor（VEGF） gene with the risk of endometriosis by meta-analysis. Methods Published case-control studies about the influence of VEGF polymorphisms on endometriosis were searched and screened in Medline, the Cochrane library, China National Knowledge Internet（CNKI）, Chinese Biological Medicine Disk （CBM）, data base of Wanfang and Foreign Medical Journal Full-Text Service（FMJS）. RevMan 5.0 software was used for meta-analysis. Results Finally, there were 9 literatures including 1610 endometrisis patients and 1643 controls cases, which were eligible for the criteria to investigating the VEGF SNP about -460C/T, ＋ 405C/G and ＋ 936C/T. The results of metaanalysis showed that there was no evidence for association between endometriosis and the VEGF -460C/T SNP in the genotype or allele frequencies distribution （ P 〉 0. 05 ）. Significant differences were found between the frequencies distribution of VEGF ＋ 405 CC genotype （P = 0. 009, OR = 1.45,95 % CI： 1.10 - 1.91 ） and ＋ 405C allele（P = 0. 020, OR = 1.19,95% CI： 1.03 - 1.38 ） , also between the ＋ 936CC genotype （ P=0. 050, OR = 0. 81,95% CI：0. 66 - 1.00） and ＋ 936T allele （ P = 0. 040, OR = 1.20,95% CI： 1.01 - 1.43 ） Conclusions The VEGF ＋ 405C/G and ＋ 936C/T SNP may be associated with the risk of endometriosis. Women carrying the ＋ 405C or the ＋ 936T allele could significantly increase the risk of developing endometriosis.