恶性实体瘤患者凝血功能相关指标的变化规律及临床意义

Study on malignant solid tumor patients blood clotting related indicators changing regularity and their clinical significance

目的探讨恶性实体瘤患者凝血功能相关指标的变化规律及临床意义。方法将120例恶性实体瘤患者按照肿瘤分期分为肿瘤早期组(25例)、局部晚期组(43例)、远处转移组(52例),选择健康体检者(40例)为对照组,分别采血定量检测血小板(PLT)计数、血浆凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、血浆纤维蛋白原(FIB)和D-二聚体(D-D)含量并进行组间对比分析。结果 (1)恶性实体瘤组与健康对照组比较,血浆PLT、PT、FIB、APTT、TT、D-D水平增高,差异具有统计学意义(P<0.05)。(2)肿瘤早期组、局部晚期组、远处转移组、健康对照组间上述各凝血指标存在差异且有统计学意义(P<0.05)。(3)远处转移组血浆FIB及D-D含量与肿瘤早期组、局部晚期组差异有统计学意义(P<0.05)。结论恶性实体瘤患者存在凝血功能异常,其血液异常状态与肿瘤分期有关,发生远处转移的恶性实体瘤患者凝血功能障碍更加明显,需密切观察FIB及D-D变化。

Objective To study the blood clotting relevant indicators changing regularity and their clinical significance on malignant solid tumor patients.Methods 120 cases of malignant solid tumor were divided into three groups: early tumor group,local-advanced tumor group,distant metastases group,the control health group is 40 cases.The quantitative detection of platelet count,prothrombin time,activated partial thromboplastin time,thrombin time,plasmatic fibrinogen and D-dimmer content in blood were analyzed for all cases.Results(1) There are statistical differences of the plasma levels of PLT,PT,FIB,APTT,TT,D-D between malignant solid tumor group and health control group(P<0.05).(2) There are statistical differences of the clotting relevant indicators mentioned above between malignant solid tumor group and health control group(P<0.05).(3) There are statistical differences of the plasma levels of FIB and D-D between malignant solid tumor group and health control group along with local-advanced group(P<0.05).Conclusion Compared with asymptomatic healthy volunteers malignant solid tumor patients exist coagulant function abnormality.Malignant solid tumor blood with abnormal state tumor stages involved;distant metastases group tumor patient blood coagulation disorders more apparent,need to closely observe FIB and D-D changes.