中药蜈蚣汤与甲氨蝶呤治疗非破裂型输卵管妊娠的对照研究

Comparative study of chinese herbs and methotrexate treatment for unruptured tubal pregnancy

目的对比观察中药蜈蚣汤与甲氨蝶呤治疗非破裂型输卵管妊娠的疗效及不良反应。方法收集保守治疗的非破裂型输卵管妊娠患者72例,分别用蜈蚣汤口服(A组,37例)和甲氨蝶呤50mg/m2单次肌注(B组,35例)治疗,比较其疗效及不良反应。结果 A组治愈率(86.5%)和B组治愈率(88.6%)比较,差异无统计学意义(P>0.05),两组在1周内血β-hCG下降>15%例数、2周内盆腔包块缩小≥30%例数、血β-hCG转阴时间、住院治疗时间等方面比较差异无统计学意义(P>0.05),但A组的胃肠道不良反应明显低于B组(P<0.05)。结论两种方法治疗非破裂型输卵管妊娠均有较好的疗效,疗效相同,但中药治疗有活血化淤作用,促进包块吸收,不良反应少,是一种安全有效的药物治疗方法,值得临床推广。

Objective To study the efficacy and side effects in the treatment of chinese herbs and methotrexate for unruptured tubal pregnancy.Methods 72 cases of unruptured tubal pregnancy were divided into two groups.Group A was treated with chinese herbs,group B was treated with intramuscular MTX（50mg/ m2）.The curative rate and side effects of the two groups were compared.Results There was no statistical significance（P0.05）in the curative rate between the group A（86.5%） and group B（88.6%）.The differences of the speed of reduction of serum β-hCG in seven days、the speed of reduction of the adnexal mass and the time for serum β-hCG normalization in the two groups were no statistical significance（P0.05）.The incidence of side effect of gastrointestinal reaction was conspicuously lower in group A（P0.05）.Conclusion Chinese herbs and methotrexate have the same effect for unruptured tubal pregnancy,but the the incidence of side effect of chinese herbs was significantly lower than methotrexate.Convenience、efficiency、safety as well as retention of reproductive capability are advantages of the chinese herbs for unruptured tubal pregnancy.