2型糖尿病患者血浆致动脉硬化指数与踝肱指数的相关性

Atherogenic index of plasma is associated with ankle brachial index in patients with type 2 diabetes mellitus

目的探讨2型糖尿病患者血浆致动脉硬化指数(atherogenic index of plasma,AIP))与踝肱指数(ankle bra-chial index,ABI)的相关性。方法纳入143例2型糖尿病患者,测定双下肢动脉血管压力和肱动脉血管压力,计算踝肱指数,测量身高、体重、血脂、肌酐、尿酸、HbA1c、超敏反应蛋白(sCRP)尿白蛋白/肌酐(ACR)、计算血浆致动脉硬化指数[log(TG/HDL-c)]。依照踝肱指数分为两组:ABI<0.9和0.9≤ABI<1.4组。结果①两组相比,AIP、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-c)、低密度脂蛋白胆固醇(LDL-c)、sCRP、ACR差异均有统计学意义(P<0.05)。②单因素分析表明,ABI与AIP、TG、TC、HDL、LDL、SCRP、ACR相关(P<0.05)。其中ABI与AIP相关系数最大r=0.484。③以ABI为因变量,以其余各因素为自变量作多元回归分析,结果表明血浆致动脉硬化指数(P<0.000)、ACR(P<0.000)、SCRP(P<0.000)进入方程。结论 AIP与2型糖尿病患者ABI具有较好的相关性,可以作为2型糖尿病患者外周血管疾病的有用指标。

Objective To investigate the relationship of atherogenic index of plasma（AIP） to ankle brachial index（ABI） in patients with type 2 diabetes.Methods 143 subjects with type 2 diabetes were included,ankle brachial index,height,weight,blood lipid,acidum uricum,creatinine,HbA1c,urine albumin to creatinine（ACR） were measured and AIP（log（TG/ HDL-c）） was calculated.The subjects were divided into two groups according to ABI：ABI≤0.9 and 0.9ABI1.4.Results ①There was significant difference in AIP,TG,HDL-c,LDL-c,sCRP,ACR（P0.05）between the two groups.②HDL-c was inversely related to ABI.AIP,TG,TC,LDL,SCRP,ACR were positively related to ABI（P0.05）.The orrelation coefficient of ABI and AIP was 0.484.③Multivariate analysis by linear regression showed that AIP（P0.000）,ACR（P0.000）,sCRP（P0.000） were included.Conclusion In patients with type 2 diabetes,AIP is an important risk factor in pathogenesis and progress of peripheral arterial disease.