伴及不伴OSA高血压患者超敏C反应蛋白和OSA的相关性研究

Relationship between hs-CRP and Obstructive Sleep Apnea in Hypertension Patients

目的研究伴及不伴睡眠呼吸暂停(obstructive sleep apnea,OSA)高血压患者的超敏C反应蛋白(high-sensitivity C-reactive pro-tein,hs-CRP)和睡眠呼吸暂停低通气指数(apnea hyperpnoea index,AHI)的相关性,揭示此类疾病与炎症反应的关系,为中西医诊治提供一定的临床研究依据。方法纳入阴虚阳亢型轻中度高血压患者96例,对患者行便携式睡眠仪监测、24h动态血压(AB-PM)监测及hs-CRP检测。采用直线回归和多元逐步回归法分析OSA和hs-CRP及血压的关系。结果与不伴OSA患者相比,伴OSA的轻中度高血压患者的hs-CRP水平明显增高(P<0.05),并且hs-CRP和AHI呈正相关。结论 hs-CRP这一炎症因子参与了伴OSA的轻中度高血压患者的疾病过程,并且与OSA的病情严重程度相关。

Objective To analyze the correlation between blood pressure,high-sensitivity C-reactive protein（hs-CRP） and obstructive sleep apnea（OSA） in hypertension patients.Methods Ninety-six mild and moderate hypertensive patients with yin deficiency and yang hyperactivity syndrome were enrolled into the study.Each one received portable sleep monitoring,24 hour ambulatory blood pressure monitoring（ABPM）.The hs-CRP was tested to explore the functional mechanism.Stepwise regression was used to analyze the correlation between OSA,blood pressure and hs-CRP.Results The hs-CRP levels in pts with OSA were significantly higher than those without OSA（P0.05）.Apnea hyperpnoea index had positive correlation with hs-CRP.Conclusion The inflammatory factor hs-CRP participated in the pathogenesis of mild and moderate hypertensive patients with OSA,and the hs-CRP level was related with the severity of OSA.