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法舒地尔联合依达拉奉治疗急性脑梗死60例疗效分析 被引量:2

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摘要 目的探讨法舒地尔联合依达拉奉治疗急性脑梗死的临床疗效。方法将120例急性脑梗死患者随机分为治疗组和对照组。治疗组予法舒地尔30mg加入生理盐水250mL静脉输注,每日2次;依达拉奉30mg加入生理盐水100mL静脉输注,每日2次,10d~14d为1个疗程。对照组予丹参注射液20mL加入生理盐水250mL静脉输注,每日1次,10d~14d为1个疗程。结果治疗组治疗后总有效率为95%,优于对照组的60%(P<0.01),治疗组治疗后神经功能缺损评分及减少分数均低于对照组(P<0.05或P<0.01)。结论法舒地尔治疗急性脑梗死疗效显著。
作者 李丽茹 黄杰
出处 《中西医结合心脑血管病杂志》 2012年第3期304-305,共2页 Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
基金 上海市奉贤区科委基金资助项目(No.奉科2010-101101)
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  • 1Nakamura K,Nishimura J,Hirano K,et al.Hydroxyfasudil,an active metabolice of fasudil hydrochloride,relaxes the rabbit basilar artery by disinibition of myosin light chain phosphatase.J Cereb Blood Flow Metab,2001,21:876-885.
  • 2Masumoto N,Tanabe Y,Saito M,et al.Attenuation of pressure-induced myogenic contraction and tyrosine phosphorylation by fasudil,a cerebral vasodilator,in rat cerebral artery.British journal of pharmacology,2000,130:219-230.
  • 3Takanashi Y,Ishida T,Meguro T,et al.A novel drug delivery system as prophylaxis for cerebral vasospasm.Acta Neurochir,2001,(Suppl) 77:213-215.
  • 4Masaoka H,Takasato Y,Nojiri T,et al.Clinic effect of fasudil hydrochloride for cerebral vasospasm following subarachnoid hemorrhage.Acta Neurochir,2001,(Suppl) 77:209-221.
  • 5Miriam M T,Bernhard W,Peter M S,et al.Systematic review of the prevention of delayed ischemic neurological deficits with hypertension,hypervolemia,and hemodilution therapy following subarachnoid hemorrhage.J Neurosurg,2003,98:978-984.
  • 6Nagumo H,Sasaki Y,Ono Y,et al.Rho-kinase inhibitor HA-1077 prevents rho-mediated myosin phosphatase inhibition in smooth muscle cells.Am J Physiol,2000.278:C57-C65.
  • 7Sasaki Y,Suzuki M,Hidaka H.The noval and specific rhokinase inhibitor (s)-(+) -2-Methyl-1-[(4-methyl-5 -isoquinoline) sulfony] -Homopiperazine as a probing molecule for rho-kinase-invlved pathway.Phrmacology & Therapeutics,2002,93:225-232.
  • 8Satoh Sh,Suzuki I,Ikegaki I,et al.The effects of HA 1077on the cerebral circulation after subarachnoid haemorrhage in dogs.Acta Neurochir (Wien),1991,110:185-188.
  • 9Shibuya M,Suzuki Y,Sugita K,et al.Effect of AT877 on cerebral vasospasm after aneurysmal subaracnoid hemorrhage.J Neurosurg,1992,76:571-577.
  • 10Shibuya M,Asano T,Sasaki Y.Effect of fasudil HCl,a protein kinase inhibitor,on cerebral vasospasm.Acta Neurochir,2000,(Suppl) 77:201-204.

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