超声评价高血压患者动脉缓冲功能

Evaluation of Arterial Buffering Function in Hypertension by Ultrasonography

目的：评价超声技术在检测高血压患者动脉缓冲功能中的应用价值。方法：对５４例原发性高血压患者和１０例正常人应用二维及多普勒超声分别对心脏和肱动脉扫查。肱动脉横断面顺应性（Ｃｒｏｓｓ－ｓｅｃｔｉｏｎａｌ Ｃｏｍｐｌｉａｎｃｅ ＣＳＣ）和容积扩张性（ＶｏｌｕｍｉｃＤｉｓｔｅｎｓｉｂｉｌｉｔｙ ＶＤ）作为反映动脉缓冲功能的指标。结果：正常对照组与高血压组相比，ＣＳＣ、ＶＤ在高血压组显著升高，分别为 ３４．８７±０．０１ １０^（－３）ｍｍ~２·ｍｍＨｇ^（－１）比 １９．８８±０．０２８ １０^（－３）ｍｍ~２·ｍｍＨｇ^（－１），Ｐ＝０．０２９；２．８６±０．８８ １０^（－３）ｍｍ~２·ｍｍＨｇ^（－１） ｖｓ１． ６１±０． ２６ １０^（－３）ｍｍ~２·ｍｍＨｇ，Ｐ＝０． ０１６５。多因素分析结果显示收缩压，左室舒张早期和晚期峰值血流速度比（Ｐｅ／Ｐａ），阻力指数（ＲＩ）是与ＣＳＣ关系最为密切的参数。结论：超声具有直观、准确、实时反映动脉缓冲功能的特点，具有广阔的应用前景。

To determine clinical value of ultra- sound in evaluating arterial buffering function in hypertension. Methods: 2-DE and Doppler ultrasonography were applied to examine 54 essential hypertensive patients and 10 healthy subjects. Brachial artery cross-sectional compliance and volumic distensibility were determined that reflect arterial buffering function. Results: Brachial artery cross-sectional compliance, volumic distensibility were higher in hypertensive patients 34. 87± 0. 01 10^(-3) mm^2 .mmHg ^(-1) vs 19. 88±0. 028 10^(-3) mm^2 .mmHg^(-1),P = 0. 029; 2. 86 ± 0. 88 10^(-3)mmHg^(-1) vs 1. 61 ± 0. 26 10^(-3). mmHg^(-1), P= 0. 0165, respectively. Mutiple regression analysis results demonstrated systolic blood pressure,left ventricular diastolic peak early filling velocity and peak late filling velocity ratio, brachial artery blood flow resistant index had close relationship with brachial artery cross-sectional compliance. Conclusion: Ultrasound could examine arterial buffering function directly,accurately and real time.