依那普利、福辛普利对自发性高血压大鼠心肌超微结构逆转的实验研究

Reversal of Cardiomuscular Ultrastructural Lesions by Enalapril or Fosinopril in Spontaneous Hypertensive Rats

目的；观察血管紧张素转换酶抑制剂ｅｎａｌａｐｒｉｌ和ｆｏｓ－ｉｎｏｐｒｉｌ对ＳＨＲ心肌超微结构的逆转作用。方法：将 １０月龄 １８只 ＳＨＲ随机分为 Ｅｎａｌａｐｒｉｌ（ＳＨＲ_Ｅ）、Ｆｏｓ－ｉｎｏｐｒｉｌ（ＳＨＲ_Ｆ）和生理盐水（ＳＨＲｃ）三组，给药剂量为 １０ ｍｇ／ｋｇ／ｄ腹腔内注射８周。测定血压、心室重量指数，电镜观察心肌超微结构改变。结果：两药物组心室肥厚均不同程度消退，部分逆转心肌超微结构改变，而且 Ｆｏｓｉｎｏｐｒｉｌ降低 ＬＶＷ／ＢＷ 比 Ｅｎａｌａｐｒｉｌ更好（Ｐ＜０．０５）。结论：福辛普利和依那普利不同程度改善心肌细胞超微结构损害。

Aim: The study was to observe the effects of angiotensin converting enzyme inhibitor enalapril and fosinopril on reversal of cardiomuscular ultrastructurein spontaneous hypertensive rats. Methods: 18 SHRs were divided into three groups at random. Enalapril or Fosinopril or saline (10 mg/kg/d) was injected intraperitoneally into each group rat. Systolic blood pressure and ventricular weight index (LVW/BW, RVW/BW) were measured. cardiomuscular ultrastructural was observed with electron-microscope. Results:The effects of enalapril and fosinopril were similar in decreasing SBP, RVW/BW. Decreased LVW/BW in fosinopril was more significantly than that by enalapril. Both drugs can partly reverse the cardiomuscular ultrastructure lesions. Conclusion: Enalapril and fosinopril lead to reverse the cardiomuscular ultrastructure at varying degrees.