L-精氨酸对肾性高血压心肌肥厚大鼠左心室肌原癌基c-fos蛋白表达及血浆NO含量的影响

The Effects of L-Arg on the Expression of Proto-oncogene c-fos in the Left Ventricle and Plasma Nitric Oxide inRats with Renovascular Hypertensive Hypertrophy

目的：探讨Ｌ－精氨酸对肾性高血压心肌肥厚大鼠左室肌原癌基因 ｃ－ｆｏｓ表达及血浆 ＮＯ含量的影响。方法：采用免疫组织化学方法测定左室肌原癌基因ｃ－ｆｏｓ蛋白表达，用比色法测定血浆一氧化氮含量。结果：通过８周治疗后，Ｌ－Ａｒｇ使高血压心肌肥厚大鼠ｃ－ｆｏｓ蛋白表达显著减少（Ｐ＜０．００５），使血浆中ＮＯ含量显著升高（Ｐ＜０，００１）结论： Ｌ－Ａｒｇ治疗高血压心肌肥厚大鼠能减轻 ｃ－ｆｏｓ表达和提高血浆中ＮＯ含量。

Objective:To study the effects of L-Arg on the expression of proto-oncogene c-fos in the left ventricle and plasma nitric oxide in rats with renovascular hypertensive hypertrophy. Methods: The level of c-fos was measured by immunohistochemical method and the plasma nitric oxide by colorimetric method. Results: After eight weeks of L-Arg p. o treatment, the expression of oncogene c-fos of the L-Arg-200 mg/kg·d^(-1) and L-Arg-400 mg/kg .d^(-1) groups decreased markedly, while the plasma nitric oxide increased significantly compared with those of 2K1C group(p<0. 01) Conclusion: The expression of proto-oncogene c-fos could be decreased and the plasma nitric oxide could be increased by LArg.