缬沙坦对自发性高血压大鼠血压和肾素-血管紧张素水平的对照研究

Role of valsartan on blood pressure and renin-angiotensin of spontaneously hypertensive rats

目的：动物实验观察缬沙坦的降压效果及其对血浆肾素活性和血管紧张素Ⅱ的影响。方法：２４只雄性１４周龄的ＳＨＲ分为生理盐水组、苯那普利组、小剂量缬沙坦和大剂量缬沙坦组，另用６只同龄雄性ＷＫＹ大鼠对照。观察用药４周前后的血压、肾素活性和血管紧张素对水平。结果：与生理盐水组、苯那普利组比较，缬沙坦的降压效果明确；大剂量缬沙坦平均下降 ４１． ７±４． ９３ ｍｍＨｇ，明显大于小剂量组的降压幅度 ２７． ７±４． ４６ ｍｍＨｇ，（Ｐ＜０．０１）。 ＳＨＲ与ＷＫＹ大鼠比较，血浆肾素活性仅在大剂量缬沙坦组明显升高；血管紧张素Ⅱ水平，大剂量缬沙坦组更为明显升高，而苯那普利组有所下降。结论：缬沙坦的降压效果优于苯那普利，苯那普利使血浆ＡｎｇⅡ水平减低，而缬沙坦使血浆ＡｎｇⅡ水平升高。在长期用药过程中，较高的血浆 Ａｎｇ Ⅱ水平对人体的影响或对器官的影响如何，尚待进一步研究。

Aim: To investigate the effect of valsartan on blood pressure and renin-angiotensin system in plasma of spontaneously hypertensive rat (SHR). Methods: 24 14-week old male SHR and copared with 6 agematched male Wistar-Kyoto rats (WKY). SHR were dicided into fourgroups (each group,n = 6), respectively fed with NS, benazepril (1 mg/kg per day), valsartan (8 mg/kg per day), valsartan (24 mg/kg per day) for 4 weeks. The systolis blood pressure(SBP) was determines by the tail-cuff method. Renin activity and angiotensin Ⅱ (Ang Ⅱ ) level in plasma were measurred by radio-immunoassay. Results:Benazepril and valsartan were lowering blood pessure significantly. 8 mg/kg per day valsartan decreased SBP by 18%, and benazepril doses of 1 mg/kg per day, by 24%, while 24 mg/kg per day valsartan can decreased 30% of blood pressure. Plasma renin activity elevated in benazepril group and valsartan groups. The level of Aug Ⅱ were higher in SHR than in WKY (P< 0. 05 ). There were significantly elevation in valsartan groups than benazepril group Conclusion:Valsartan had significantly effect on BP. Simultaneously, valsartan elevatd level of plasma Ang Ⅱ, but renin actiivity only changed in a little.