胃肠道间质瘤切除术后复发危险因素的初步研究

Analysis of the risk factors for recurrence of gastrointestinal stromal tumors after resection

目的 初步研究胃肠道间质瘤切除术后复发的危险因素。方法 回顾性分析铜陵市人民医院胃肠外科2005年12月-2010年12月行手术治疗的61例胃肠道间质瘤患者的临床、病理及随访资料，采用Logistic逐步回归模型计算患者术后复发的危险因素。结果共61例患者纳入研究，行胃大部切除或全胃切除术40例，小肠部分切除术7例，结肠部分切除3例，Dixon术2例，肿瘤摘除术9例。15例患者术后给予甲磺酸伊马替尼治疗。术后4例患者失访，57例随访时间均超过1年，术后复发率为12．3％。Logistic逐步回归模型证实肿瘤恶性风险程度是最终危险因素（P=0．021）。结论 胃肠道间质瘤恶性风险程度是评估术后复发的重要指标。恶性风险程度评分较高的患者，术后给予甲磺酸伊马替尼治疗可能改善患者的短期预后。

Objective To investigate the postoperative risk factors for gastrointestinal stromal tumors. Methods From December 2005 to December 2010, sixty-one gastrointestinal stromal tumors patients of People＇ s Hospital of Tongling city gastrointestinal surgery department were analyzed retrospectively. Using the logistic regression model to calculate the postoperative recurrence risk factors. Results Sixty-one patients underwent operation, including gastrectomy （40 cases）, partial intestina parva resection （ 7 cases）, partial colon resection （ 3 cases）, Dixon＇ s operation （ 2 cases ） and tumorectomy （ 9 cases ）. Fifteen patients were given postoperative imatinib Mesylate Capsules （Glivec） treatment. Fifty-seven patients were followed-up more than 1 year and 7 cases were found palindromia （ 12% ）. Logistic model shows that the malignant degree of gastrointestinal stromal tumors is the only risk factor of postoperative palindromia. Conehtsions Malignant degree of gastrointestinal stromal tumors is the main risk factor for postoperative palindromia. Imatinib mesylate capsules treatment may be beneficial to the greater stage patients.