亚胺培南与头孢哌酮舒巴坦治疗肝硬化自发性腹膜炎的疗效比较

Comparison of clinical efficacy of imipenem and cefoperazone sulbactam in treatment of spontaneous bacterial peritonitis of liver cirrhosis

目的比较亚胺培南与头孢哌酮舒巴坦治疗肝硬化自发性腹膜炎的临床疗效。方法 70例肝硬化自发性腹膜炎患者分成亚胺培南组(A组,35例)和头孢哌酮舒巴坦组(B组,35例),A组采用腹腔穿刺引流及亚胺培南治疗,B组采用腹腔穿刺引流及头孢哌酮舒巴坦治疗,两组疗程均为10 d。治疗结束后观察两组疗效及临床症状变化情况。结果 A组治疗总有效率(82.9%)明显优于B组(68.6%)(P<0.05);A组发热、腹胀、腹痛、腹部压痛和反跳痛等临床症状缓解时间明显早于B组(P<0.05)。结论亚胺培南治疗肝硬化自发性腹膜炎疗效显著,不良反应少,可明显缓解临床症状,值得临床推广应用。

Objective To compare the curative effect of imipenem and cefoperazone sulbactam in treatment of spontaneous bacterial peritonitis of liver cirrhosis. Methods Seventy patients with spontaneous bacterial peritonitis of liver cirrhosis were divided into imipenem group（A group,35 cases） and cefoperazone sulbactam group（B group,35 cases）.A group was treated with abdominal puncture combined with imipenem,and B group was treated with abdominal puncture combined with cefoperazone sulbactam.The cure time of two groups was 10 days.The treatment effects,the changes of clinical symptoms were observed after treatment. Results The total effective rate of A group（82.9%） was significantly better than that of B group（68.6%）（P0.05）.The remission time of clinical symptoms in A group after treatment was earlier than that of B group（P0.05）. Conclusion The treatment of imipenem for spontaneous bacterial peritonitis of liver cirrhosis has a good effect.It could alleviate the clinical symptoms and be worthy of clinical application.