期刊文献+

舒郁宁心汤对抑郁大鼠海马Bcl-2和Bax表达的影响 被引量:4

Effect of Shuyuningxin Decoction on the Expression of Bcl-2 and Bax in Hippocampus of Chronic Stress Depression Rats
下载PDF
导出
摘要 目的了解舒郁宁心中药对慢性应激抑郁模型大鼠海马区凋亡调控蛋白Bcl-2和Bax表达的影响。方法 60只SD大鼠随机分为对照组,模型组,高、中、低剂量组和盐酸氟西汀组。复制孤养加慢性轻度不可预见性应激抑郁模型,造模成功后进行药物干预21 d。采用免疫组化方法观察大鼠海马区Bcl-2和Bax表达。结果与对照组比较,模型组大鼠Bax表达升高、Bcl-2表达降低(P<0.05);与模型组相比,中剂量组、高剂量组、盐酸氟西汀组大鼠海马区Bax表达降低、Bcl-2表达升高(P<0.05)。结论舒郁宁心汤可能通过调控海马组织Bcl-2和Bax的表达,对抗海马神经元凋亡,发挥抗抑郁作用。 Objective To investigate the effect of Shuyuningxin decoction on the expression of Bcl-2 and Bax in hippocampus of chronic stress depression rats.Methods 60 SD rats were randomly divided into control group,model group,fluoxetine group,high dose of Shuyuningxin decoction group,middle dose of Shuyuningxin decoction group and low dose of Shuyuningxin decoction group.All the groups were given the chronic unpredicted mild stress for 21 d to induce depression models except the control group.Then they were administrated their drugs for 21 d.The level of Bcl-2 and Bax in hippocampus were investigated with immunohistochemistry technique.Results Compared with the control group,the level of Bax increased and Bcl-2 decreased in the model group(P0.05).Compared with model group,the level of Bax decreased and Bcl-2 increased in the middle dose of Shuyuningxin decoction group,high dose of Shuyuningxin decoction group and the fluoxetine group(P0.05).Conclusion The anti-depression effect of Shuyuningxin decoction may be associated with the expression of Bax and Bcl-2.
出处 《中国康复理论与实践》 CSCD 北大核心 2012年第3期236-238,共3页 Chinese Journal of Rehabilitation Theory and Practice
基金 北京市科技计划基金课题(Z090507017709030) 军队十二五攻关课题(CWS11J67)
关键词 舒郁宁心汤 抑郁 BCL-2 BAX Shuyuningxin decoction depression Bcl-2 Bax
  • 相关文献

参考文献7

  • 1沈渔邨.精神病学[M].5版.北京:人民卫生出版社.2009:838.
  • 2Duman RS,Kehne JH.Depression[J].CNS Neurol DisordDrug Targets,2007,6(3):161-162.
  • 3李卫晖,李凌江,刘哲宁.热休克蛋白——细胞应激反应的生物标志[J].国外医学(精神病学分册),2002,29(4):248-250. 被引量:23
  • 4Winner P,Towell A,Sampson D,et al.Reduction of sucrosepreference by chronic unpredictable mild stress,and its restora-tion by a tricyclic antidepressant[J].Psychopharmacology,1987,93:358-364.
  • 5诸葛启钏,译.大鼠脑立体定位图谱[M].3版.北京:人民卫生出版社,2005:43-51.
  • 6De Vry J,Schreiber R.The chronic mild stress depression mod-el:future developments from a drug discovery perspectivel[J].Psychopharmacology,1997,134:349-350.
  • 7董爱国,赵丽丽,李海红.BDNF在抑郁症发病机制中的作用及其抗抑郁作用机制的研究进展[J].中国医疗前沿,2011,6(6):16-18. 被引量:24

二级参考文献25

  • 1M Grataco's, V Soria, M Urretavizcaya, et al. A brainderived neurotrophic factor(BDNF) haplotype is associated with antidepressanttreatment outcome in mood disorders[J].The Pharmacogenomics Journal, 2008, (8): 101-112.
  • 2D Taliaz, N Stall. Knockdown of brain-derived neurotrophic factor in specific brain sites precipitates behaviors associated with depression and reduces neurogenesis[J],Molecular Psychiatry,2010, (15): 80-92.
  • 3Alessia Bachisl, Alessandra Malleil. Chronic antidepressant treatments increase basic fibroblast growth factor and fibroblast growth factor-binding protein in neurons[J]. Neuropharmacology, 2008,55(7) : 1114-1120.
  • 4Bun-Hee Lee, Hyun Kim, Sun-Hwa Park, et al. Decreased plasma BDNF level in depressive patients[J]. Journal of Aflective Disorders, 2007, (101) :239-244.
  • 5Yong-Ku Kim, Heung-Pyo Lee, Sung-Doo Won, et al. Low plasma BDNF is associated with suicidal behavior in major depression[J] . Progress in Neuro-Psychopharmacology & Biological Psychiatry, 2007, (31 ): 78-85.
  • 6Brian A, Hoshaw, Jessica E. Malberg and Irwin Lucki . Central administration of IGF-1 and BDNF leads to long-lasting antidepressant-like effects[JJ.Brain Research,2005,(1037)..204-208.
  • 7M PaV1, H KOVa, A FIEROVa, et al. Neurobiological Aspects of Depressive Disorder and Antidepressant Treatment.. Role of Giia[J]. Physiol Res, 2008, (57): 151-164.
  • 8Jeffrey Goodman, Helen Scharfman, Adam Macleod, et al. Increased neurogenesis and the ectopic granule ceils after intrahippocampal BDNF infusion in aduit rats[J].Experimental Neurology, 2005, (192): 348-356.
  • 9Tiao-Lai Huang, Chien-Te Lee, Yu-Li Liu. Serum brainderived neurotrophic factor levels in patients with major depression: Effects of antidepressants[J]. Journal of Psychiatric Research, 2008, (42): 521-525.
  • 10Morena Zusso, Patrizia Debetto. Fluoxetine-induced proliferation and differentiation of neural progenitor cells isolated from rat postnatal cerebellum[J].Biochemicl Pharmacology,2008, (76) :391-403.

共引文献294

同被引文献85

引证文献4

二级引证文献13

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部