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N-甲基-D-天门冬氨酸受体、脑缺血性损伤和运动训练 被引量:2

N-methyl-D-aspartate Receptor,Cerebral Ischemia and Exercise(review)
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摘要 N-甲基-D-天门冬氨酸(NMDA)受体是一种离子型谷氨酸受体,与突触可塑性、皮质和海马神经元长时程增强和抑制效应等中枢神经系统的生理、病理过程相关。本文就近年来NMDA受体在脑缺血中所起作用的研究进展进行综述。 N-methyl-D-aspartate(NMDA) receptors are a group of ionotropic glutamate receptors,which are in close contact with the synaptic plasticity,long-term potentiation(LTP) and long-term depression(LTD) in the cerebral cortex or the hippocampus.This article reviewed the recent development in this field.
出处 《中国康复理论与实践》 CSCD 北大核心 2012年第3期247-249,共3页 Chinese Journal of Rehabilitation Theory and Practice
基金 上海卫生局科研课题(2009-250) 上海闸北区卫生重点项目(2011ZD07)
关键词 N-甲基-D-天门冬氨酸受体 脑缺血 运动 综述 N-methyl-D-aspartate receptor cerebral ischemia exercise review
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  • 1Sugihara H,Moriyoshi K,Ishii T,et al.Structures and proper-ties of seven isoforms of the NMDA receptor generated by al-ternative splicing[J].Biochem Biophys Res Commun,1992,185:826-832.
  • 2Watanabe M,Inoue Y,Sakimura K,et al.Distinct distributions of five N-methyl-D-aspartate receptor channel subunit mRNAs in the forebrain[J].J Comp Neurol,1993,338:377-390.
  • 3伍国锋(综述),洪震(审校).NMDA受体在突触调控中的作用[J].临床神经电生理学杂志,2009(3):182-183. 被引量:6
  • 4Sirear R.Developmental maturation of the N-methyl-D-aspar-tic acid receptor channel complex in postnatal rat brain[J].Int J Dev Neurosci,2000,8(1):121-131.
  • 5Thoflas E,Bartlett NJ,Bannister VJ,et al.Differential roles of NR2A and NR2B-containing NMDA receptors in LTP and LTD in the CA1region of two week old rat hippocampus[J].Neuropharmacology,2007,52(1):60-70.
  • 6Clarke RJ,Johnson JW.Voltage-dependent gating of NR1/2B NMDA receptors[J].Physiology,2008,586(23):5727-5741.
  • 7Zhang XL,Sullivan JA,Bloskal JR,et al.A NMDA receptor glycine site partial agonist,GLYX-13,simultaneously enhanc-es LTP and reduces LTD at Schaffer collateral-CA1synapses in hippocampus[J].Neuropharmacology,2008,55(7):1238-1250.
  • 8Lyden P,Wahlgren NG.Mechanisms of action of neuroprotec-tants in stroke[J].J Stroke Cerebrovasc Dis,2000,9(6,S2):9-14.
  • 9Chen M,Lu TJ.Differential roles of NMDA receptor subtypes in ischemic neuronal cell death and ischemic tolerance[J].Stroke,2008,39:3042-3048.
  • 10Liu TP,Wong M,Aarts A,et al.NMDA receptor subunits have differential roles in mediating excitotoxic neuronal death both in vitro and in vivo[J].J Neurosci,2007,27(11):2846-2857.

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  • 1彭涛,方树友,冯明,方桂远.Guillain-Barré综合征患者血清和脑脊液IL-18、IL-13水平的测定及临床意义[J].中国神经精神疾病杂志,2006,32(4):363-365. 被引量:4
  • 2李春晖,焦保华.转染IL-18的骨髓基质干细胞对大鼠脑胶质瘤的作用[J].癌症,2007,26(1):38-43. 被引量:9
  • 3李森美,陈荣波,吴丽萍,巫顺秀.多发性硬化患者白介素18的表达与临床相关研究[J].神经疾病与精神卫生,2007,7(6):419-421. 被引量:2
  • 4BossùP,Ciaramella A,Salani F,et al .Interleukin 18,from neu- roinflammation to Alzheimer’s disease [J]. Curr Pharm Des,2010,16(38):4213-4224.
  • 5Soltani A,Clark WM,Hansmann DR,et al .Sonothrombolysis:anemerging modality for the treatment of acute ischemic and hem- orrhagic stroke[J].Transl Stroke Res,2011,2(2):159-170.
  • 6Hedtj-rn M,Leverin AL,Eriksson K,et al . Interleukin 18 in- volvement in hypoxic ischemic brain injury [J]. J Neurosci,2002,22(14):5910-5919.
  • 7Jander S,Stoll G.Differential induction of interleukin 12,inter-leukin 18,and interleukin 1beta converting enzyme mRNA inexperimental autoimmune encephalomyelitis of the Lewis rat[J].J Neuroimmunol,1998,91(1 2):93-99.
  • 8Zaki MH,Vogel P,Body Malapel M,et al . IL 18 productiondownstream of the Nlrp3 inflammasome confers protection a- gainst colorectal tumor formation[J].J Immunol,2010,185(8):4912 4920.
  • 9Kim KE,Song H,Hahm C,et al .Expression of ADAM33 is a no- vel regulatory mechanism in IL 18 secreted process in gastriccancer[J].J Immunol,2009,182(6):3548 -3555.
  • 10Kang JS,Bae SY,Kim HR,et al .Interleukin 18 increases me- tastasis and immune escape of stomach cancer via the downreg- ulation of CD70 and maintenance of CD44[J].Carcinogenesis,2009,30(12):1987-1996.

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