扩充痴呆量表对慢性阻塞性肺疾病认知功能的评价

Extended Scale for Dementia on Cognitive Function of Patients with Chronic Obstructive Pulmonary Disease

目的探讨扩充痴呆量表(ESD)对稳定期慢性阻塞性肺疾病(COPD)患者认知功能的评价作用。方法稳定期COPD患者37例(COPD组)根据动脉血氧分压(PaO2)分组;同期北京市城区健康居民40名为对照组。两组均采用ESD及简易智能精神状态检查量表(MMSE)进行评定。结果 COPD组ESD总分及学习、记忆、计算、结构4项分测验评分均显著低于对照组(P<0.001)。COPD组MMSE总分及注意力和计算力、回忆能力、记忆力3项分测验评分均低于对照组(P<0.05)。PaO2<60 mmHg COPD患者ESD总分及学习、记忆力和计算力3项分测验评分均低于PaO2≥60 mmHg COPD患者(P<0.05),MMSE总分及注意力和计算力、回忆能力、记忆力3项分测验评分也低(P<0.05)。ESD总分、MMSE总分与PaO2均明显相关(P<0.01)。结论 ESD可以作为评价稳定期COPD患者认知功能的工具。

Objective To evaluate the cognitive function of chronic obstructive pulmonary disease（COPD） stable patients with Extended Scale for Dementia（ESD）.Methods 37 patients with stable COPD（COPD group） and 40 healthy persons（control group） were enrolled.The COPD patients were divided into different groups as their PaO2.They were assessed with ESD and Mini Mental Status Examination（MMSE）.Results The total score of ESD and the subtest scores of ESD in leaning,memory,calculation,constructive function were significantly lower in the COPD group than in the control group（P0.001）.The total score of MMSE and the subtest scores of MMSE in memory,attention and calculation,short-and long-term memory were significantly lower in the COPD group than in the control group（P0.05）.The total score and the subtest scores in learning,memory,calculation of ESD were lower in patients with PaO260 mmHg than those with PaO2≥60 mmHg（P0.05）,same as the total score and the subtest scores in memory,attention and calculation,short-and long-term memory of MMSE（P0.05）.Both ESD and MMSE correlated significantly with PaO2（P0.01）.Conclusion ESD can be used as an evaluation tool for cognitive function in stable patients with chronic obstructive pulmonary disease.