非外伤性横纹肌溶解症的临床特点

Clinical Features of Non-traumatic Rhabdomyolysis:11 Cases Report

目的了解非外伤性横纹肌溶解症(RM)的临床特点和发病机制。方法对11例非外伤性RM的病因和临床表现进行回顾性分析。结果本组病因包括药物性3例,一氧化碳中毒2例,高强度运动2例,高强度农业劳动1例,其他3例。临床表现为肌无力、肌痛、肌肿胀、茶色尿、肾功能衰竭,实验室检验包括肌酸激酶增高,各种电解质紊乱。结论药物是引起非外伤性RM的主要原因,诊断主要依据临床表现和血清肌酸激酶显著升高。急性肾功能衰竭是其严重和导致死亡的主要并发症。

Objective To study the clinical features and pathogenesis of non-traumatic rhabdomyolysis（RM）.Methods The causes and clinical features of 11 patients with non-traumatic RM were analyzed retrospectively.Results The causes of non-traumatic RM included drugs（3 cases）,carbon monoxide poisoning（2 cases）,intensive exercise training（2 cases）,strenuous farming work（1 cases） and others（3 cases）.The clinical presentations included muscular weakness,myalgia,muscle swelling,pigmented urine and acute renal failure.The activity of serum creatine kinase increased,electrolyte derangements were common complications.Conclusion Prescribed drugs are the most common cause of non-traumatic RM.The diagnosis of non-traumatic RM is chiefly based on clinical presentations and high levels of serum creatine kinase.Acute renal failure is the most severe complication and cause of death.