盐敏感性高血压及其相关因素的家庭聚集性研究

A FAMILIAL AGGREGATION STUDY ON SODIUM SENSITIVE HYPERTENSION AND ITS RELATED FACTORS

研究盐敏感性及其相关因素的家庭聚集现象。对5个原发性高血压家系成员进行盐水负荷与利钠缩容试验的盐敏感性测定,并测定红细胞Na+浓度以及盐水负荷后Na+排泄量。结果:4个家系中约50%成员为盐敏感性,且其中80%为先证者的一、二级亲属,而第5个家系成员中仅2.5%为盐敏感者;盐敏感性的有关变量,在父/母与子女之间及同胞兄妹之间有显著相关性(P<<0.01及P<0.05)。结果提示:盐敏感性及其相关因素存在与遗传有关的家庭聚集现象。

To investigate the familial aggregation of sodium sensitive hypertension and its related factors. Methods:5 essential hypertensive pedigrees were tested for sodium sensitivity with saline load and furosemide sodium-volume depletion test. Intra-erythrocytic Na+, urinary Na+ excretion after saline load were measured. Results:The results showed that about 50% members of 4 pedigrees were tested as sodium sensitive, and 80% among those members with sodium sensitivity were the first and second relatives of the probands. In the fifth pedigree, there was only 2.5% of the members were sodium sensitive. The related variables of sodium sensitivity based on parent-offspring correlation and sib-sib correlation were significant ( P <0.01 and P <0.05). Conclusions:These results suggest that sodium sensitivity and its related factors are familial aggregated which is related with heredity.