有机碱催化下乳酸乙酯乙酸酯的合成

Synthesis of ethyl acetolactate catalyzed by organic bases

在1-甲基咪唑等有机碱催化下,乳酸乙酯与乙酸酐经乙酰化反应高效合成乳酸乙酯乙酸酯。单因素优化法得到适宜的反应条件为:1-甲基咪唑为催化剂,催化剂用量为乳酸乙酯物质的量的5.00%,n(乳酸乙酯)∶n(乙酸酐)=1∶1.2,回流反应2 h,目标产物乳酸乙酯乙酸酯收率为98.5%。该方法反应时间短,产物收率高,操作简便,具有工业化应用前景。

Using organic base 1-methyl imidazole as the catalyst,ethyl acetolactate was efficiently synthesized by acetylation of ethyl lactate with acetic anhydride. The results showed that the yield of the objective product ethyl acetolactate of 98.5% was attained under the optimum reaction condition as follows ： the dosage of the catalyst 1-methyl imidazole 5.00% （ molar ratio） of ethyl lactate amount, n （ ethyl lactate ） ： n （acetic anhydride） = 1： 1.2, and reaction time 2 h. It is a promising route for industrial production of ethyl acetolactate due to its advantages such as short reaction time,high product yield and facile operation.