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慢性乙型肝炎——疗效预测和优化治疗研究进展 被引量:7

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摘要 我国有慢性乙型肝炎(CHB)患者约3 000万,每年约有30万人死于乙型肝炎相关性肝硬化、肝癌及终末期肝病,给社会带来沉重的经济负担.CHB抗病毒治疗的目标是最大限度地长期抑制病毒复制,从而延缓肝脏疾病的进展,减少肝硬化、肝细胞癌或肝功能衰竭的发生.近年来,CHB的治疗已取得了长足的进步,目前用于CHB抗病毒治疗的药物包括两大类:α-干扰素类(普通干扰素、聚乙二醇化干扰素α-2a和α-2b),核苷(酸)类似物(拉米夫定、阿德福韦酯、恩替卡韦、替比夫定和替诺福韦酯).
出处 《肝脏》 2012年第2期73-78,共6页 Chinese Hepatology
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  • 1Buster EHCJ,Hansen BE,Lau GKK,et al.factors that predict response of patients with hepatitis B e antigen positive chronic hepatitis B to peginterferon-alfa.Gastroenterology,2009,137: 2002-2009.
  • 2European Association for the Study of the Liver.EASL Clinical Practice Guidelines:management of chronic hepatitis B.J Hepatol,2009,50:227-242.
  • 3Lok ASF,McMahon BJ:Chronic hepatitis B:Update 2009. Hepatology,2009,50:661-662.
  • 4Lau GKK,Marcellin P,Brunetto M,et al.On-treatment monitoring of HBsAg levels to predict response to peginterferon alfa-2a in patients with HBeAg-positive chronic hepatitis B.J Hepatol,2009,50:917.
  • 5Brunetto MR,Moriconi F,Bonino F,et al.Hepatitis B virus surface antigen levels:a guide to sustained response to peginterferon alfa-2a in HBeAg-negative chronic hepatitis B. Hepatology,2009,49:1141-1150.
  • 6Moucari R,Mackiewicz V,Lada O,et al.Early serum HBsAg drop:A strong predictor of sustained virological response to pegylated interferon alfa-2a in HBeAg-negative patients. Hepatology,2009,49:1151-1157.
  • 7Rijckborst V,Hansen BE,Cakaloglu Y,et al.Early on-treatment prediction of response to peginterferon alfa-2a for HBeAg-negative chronic hepatitis B using HBsAg and HBV DNA levels. Hepatology,2010,52:454-461.
  • 8Chan HLY,Thompson A,Martinot-Peignoux M,et al.Hepatitis B surface antigen quantification:Why and how to use it in 2011-A core group report.J Hepatol,2011,55:1121-1131.
  • 9Hou J,Ma H,Sun J,et al.Baseline and early on treatment characteristics in HBeAg positive patients with chronic hepatitis B (CHB) infection achieving an early on-treatment response to peginterferon alfa-2a:interim results from the RGT study. Hepatology,2011,54(Suppl):1021.
  • 10Liaw YF,Gane E,Leung N,et al.2-year GLOBE trial results: Telbivudine is superior to lamivudine in patients with chronic hepatitis B.Gastroenterology,2009,136:486-495.

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