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高尔基体蛋白73在肝癌诊断中的意义 被引量:9

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摘要 肝细胞癌(HCC)是我国常见的恶性肿瘤之一,其恶性程度高、进展快、预后差、侵袭性强,死亡率高,临床诊断时多属中晚期,及早诊断发现对提高患者存活率至关重要。甲胎蛋白(AFP)被认为是诊断HCC的重要指标,但其敏感性并不理想,30%~40%HCC患者呈阴性或低浓度。高尔基体蛋白73(GP73)是一种新近发现的HCC相关蛋白,研究表明其是肝癌诊断和鉴别诊断中一种潜在的肿瘤标志物[1-2]。本研究通过分析HCC患者血清GP73(GP73)和AFP水平,探讨它们在HCC诊断中的意义。
作者 吕新华
出处 《肝脏》 2012年第2期104-105,共2页 Chinese Hepatology
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参考文献9

  • 1Marrero JA,Romano PR,Nikolaeva O,et al.GP73,a resident Golgi glycoprotein,is a novel serum marker for hepatocellular carcinoma.J Hepatol,2005,43:1007-1012.
  • 2Riener MO,Stenner F,Liewen H,et al.Golgi phosphoprotei2( GOLPH2) expression in liver tumors and it's value as a serum marker in hepatocellular carcinomas.Hepatology,2009,49:1602- 1609.
  • 3Block TM,Comunale MA,Lowman M,et al.Use of targeted g[ycoproteomics to identify serum glycoproteins that correlate with liver cancer in woodchucks and humans.Proc Natl Acad Sci USA, 2005,102:779-784.
  • 4庞家宝.甲胎蛋白诊断原发性肝癌的局限性[J].中国误诊学杂志,2006,6(5):875-876. 被引量:15
  • 5Kladney RD,Cui X,Bulla GA,et al.Expression of GP73,a resident Golgi membrane protein,in viral and nonviral liver disease.Hepatology,2002,35:1431-1440.
  • 6Block TM,Comunale M A,Low man M,et al.Use of targeted glycoproteomics to identify serum glycoproteins that correlate with liver cancer in woodchucks and humans.Proc Natl Aead Sci USA, 2005,102:779-784.
  • 7Marrero JA,Romano PR,Nikolaeva O,et al.GP73,a resident Golgi glycoprotein,is a novel serum marker for hepatoeellular carcinoma.Hepatology,2005,43:1007-1012.
  • 8Iftikhar R,Kladney RD,Havlioglu N,et al.Disease and cell specific expression of GP73 in human liver disease. Gast roent erology,2004,99:1087-1095.
  • 9Cassandra W.Researchers look for‘sweet' method to diagnose cancer.Nature Medicine.2007,13:1107-1267.

二级参考文献2

  • 1潘中允.放射性核素诊断学[M].第2版.北京:原子能出版社,1994.297.
  • 2NaKano S.Clincal sigificance of serm ferritin[J].Am J Gastroenterol,1998,79(8):623-626.

共引文献14

同被引文献116

  • 1赛文莉,姚登福,吴玮,邱历伟,杨君伶,张海健,蔚丹丹,秦呈林.外周血高尔基体糖蛋白-73表达水平对肝细胞癌的诊断与鉴别诊断价值[J].中华临床医师杂志(电子版),2011,5(24):7382-7385. 被引量:4
  • 2Jong Young Choi,Seung Won Jung,Hee Yeon Kim,Myungshin Kim,Yonggoo Kim,Dong Goo Kim,Eun-Jee Oh.Diagnostic value of AFP-L3 and PIVKA-Ⅱin hepatocellular carcinoma according to total-AFP[J].World Journal of Gastroenterology,2013,19(3):339-346. 被引量:62
  • 3周晓华.诊断医学统计学[M].宋清华,译.北京:人民卫生出版社,2005:139.
  • 4Altekruse SF, McGlynn KA, Reichman ME. Hepatocellular carcinoma incidence, mortality, and survival trends in the United States from 1975 to 2005[J]. J Clin Oncol, 2009, 27(9): 1485- 1491.
  • 5Vanhooren V, Liu XE, Franceschi C, et al. Nglycan profiles as tools in diagnosis of hepatocellular carcinoma and prediction of healthy human ageing[J]. Mech Ageing Dev, 2009, 130( 1/2):92-97.
  • 6Kladney RD, Bulla GA, Guo L, et al. GP73, a novel Golgilocalized protein upregulated by viral infection[J]. Gene, 2000, 249(1/2): 53-65.
  • 7Mao Y, Yang H, Xu H, et al. Golgi protein 73 (GOLPH2) is a valuable serum marker for hepatocellular carcinoma [J]. Gut, 2010, 59(12): 1687-1693.
  • 8Marrero JA, Romano PR, Nikolaeva O, et al. GP73, a resident Golgi glycoprotein, is a novel serum marker for hepatoceUular carcinoma[J].J Hepatol, 2005, 43(6): 1007-1012.
  • 9Mao Y, Yang H, Xu H, et al. Golgi protein 73 (GOLPH2) is a valuable serum marker for hepatocellular carcinoma[J]. Gut, 2010, 59(12):1687-1693.
  • 10Hu JS, Wu DW, Liang S, et al. GP73, a resident Golgi glycoprotein, is sensibility and specificity for hepatocellular carcinoma of diagnosis in a hepatitis B-endemic Asian population[J]. Med Oncol, 2009, 27(2): 339-345.

二级引证文献42

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