HtrA2/Omi、XIAP和Caspase-3在银屑病皮损中的表达

Expression of HtrA2/Omi,XIAP and Caspase - 3 in lesions of patients with psoriasis

目的:检测HtrA2/Omi,X染色体连锁凋亡抑制剂(X-linked inhibitor of apoptosis,XIAP)和半胱天冬酶-3(Caspase-3)在寻常型银屑病(PV)中的表达。方法:应用免疫组化SABC法检测30例PV皮损与10例正常人皮肤中HtrA2/Omi、XIAP和Caspase-3的表达,并分析HtrA2/Omi、XIAP和Caspase-3表达之间的相关性。结果:PV皮损中XIAP和Caspase-3阳性细胞数明显高于正常皮肤(P<0.01),HtrA2/Omi阳性细胞数与正常皮肤无明显差异(P>0.05)。Caspase-3阳性细胞数和XIAP呈正相关趋势(P<0.05),与HtrA2/Omi表达无明显相关性(P>0.05)。HtrA2/Omi和XIAP的表达无明显相关性(P>0.05)。结论:XIAP和Caspase-3可能在PV的发病中起重要作用。

Objective： To detect the expression of HtrA2/Omi, X - linked inhibitor of apoptosis （XIAP） and Caspase - 3 in psoriatic lesions. Methods： SABC immunohistochemistry was used to detect the expression of HtrA2/ Omi, XIAP and Caspase - 3 in the lesions of 30 patients with psoriasis vuigaris （PV） and 10 healthy volunteers. The correlation of HtrA2/Omi, XIAP and Caspase - 3 was analyzed. Results： Compared to normal skin, the expression of ）GAP and Caspase - 3 were increased in PV lesions （ P 〈 0.01 ）, but no difference was found between HtrA2/Omi and normal skin （ P 〉 0.05）. In psoriatic lesion, the level of Caspase - 3 was positively correlated with ）GAP （ P 〈 0.05）, while there was no significant correlation between the level of Caspase - 3 and HtrA2/Omi （ P 〉 0.05）, and between HtrA2/Omi and ）GAP （ P 〉 0.05）. Conclusion： ）GAP and Caspase- 3 may play an important role in the pathogenesis of psoriasis vulgaris.