止痛消结丸对乳腺增生病模型大鼠血清MDA、PRL的影响

Effects of Zhitong Xiaojie pills on serum MDA and PRL of rats with mammary glands hyperplasia

目的:观察止痛消结丸对乳腺增生病大鼠的治疗效果及作用机制。方法:将70只大鼠随机分7组,以雌激素、孕激素建立大鼠乳腺增生病模型(空白对照组除外),观察止痛消结丸对乳腺增生病大鼠丙二醛(MDA)及催乳素(PRL)水平的影响。结果:与空白对照组比较,模型对照组大鼠血清MDA和PRL的含量显著降低(P<0.01);与模型组对照组比较,止痛消结丸大、中剂量组,乳癖消组大鼠血清MDA及PRL的含量明显降低(P<0.01)。结论:止痛消结丸可通过调节乳腺增生病大鼠MDA和PRL的水平,而达到治疗和逆转乳腺增生病的作用。

Objectives:To observe the effects of Zhitong Xiaojie(ZTXJ) pills on rats with mammary glands hyperplasia(MGH) and explore the treating mechanism.Methods:Total 70 rats were randomly divided into seven groups.The estrogen and progesterone were used to establish MGH models(except the blank group).To observe the effects of ZTXJ pills on the malondialdehyde(MDA) and prolactin(PRL).Results:Compared with the control group,serum MDA and PRL were significantly decreased in model group.Compared with model group,serum MDA and PRL were significantly decreased in the large dosage and medium dosage of ZTXJ pills and Rupixiao group.Results:ZTXJ pills can treat MGH by regulating the levels of MDA and PRL.