低分子肝素钠凝胶透皮吸收研究

Study on the Transdermal Absorption of Low Molecular Weight Heparin Sodium Gel

目的 :考察不同浓度的透皮吸收促进剂对低分子肝素钠透皮吸收的影响。方法 :采用大鼠离体皮肤和自制体外释放透皮装置试验。结果 :5 %的N 甲基 2 吡咯烷酮作为透皮吸收促进剂是适当的。结论

Purpose:To observe the effect of transdermic absorptio n enhancer of different concentrations on the transdermic absorption of low molecu lar weight heparin sodium.Methods:We carried out the trial by using separated skin of rats and -in vitro- release transdermic instrument mad e by ourselves.Results:As a transdermic absorption enhancer 5% NMP i s appropriate.Conclusion:The skin penetration of LMWH is zero grade kinetics.