福建省胃癌高中发区居民血清PG和幽门螺杆菌感染调查

Investigation of levels of serum pepsinogen and antibody to Helicobacter pylori in inhabitant of areas with high and medium incidence of gastric cancer in Fujian

目的了解福建省胃癌高发和中发区的居民血清胃蛋白酶原(PG)水平和幽门螺杆菌(Hp)感染状况。方法采集胃癌高发的长乐市和中发的同安区居民血清样本,以ELISA法检测血清胃蛋白酶原I、II(PG I、PG II)和Hp抗体。结果长乐市和同安区居民的血清PG I分别为110.8μg/L和131.0μg/L;PG II分别为13.9μg/L和14.7μg/L;两者的比值(PG I/II)分别为7.9和8.7;Hp感染率分别为49.6%和33.5%。结论两地居民的血清PG水平与Hp感染率有显著差异。

Objective To investigate the levels of serum pepsinogen（PG） Ⅰ,Ⅱ,and antibody to Helicobacter pylori（Hp） in inhabitants of areas with high and medium incidence of gastric cancer in Fujian Province.Methods The serum samples were obtained from Changle city（with high incidence of gastric cancer） and Tongan District（with medium incidence of gastric cancer）.The concentrations of serum PG Ⅰ,Ⅱ,and Hp antibody were determined by using ELISA.Results The concentrations of serum PG Ⅰ in inhabitants of Changle and Tongan were 110.8μg/ L and 131.0μg/ L,PG Ⅱ were 13.9μg/ L and 14.7μg/ L,and the ratio of PG Ⅰ/PG Ⅱ（PG Ⅰ/Ⅱ） were 7.9 and 8.7,respectively.The positive rates of Hp infection were 49.6% and 33.5% in Changle and Tongan respectively.Conclusion These serum parameters are statistically different in inhabitants between areas with high and medium incidence of gastric cancer.