HBsAg携带者补硒对HBV转归的影响

Negative returning effect on HBV markers by adding selenium to carriers

目的 了解 HBs Ag携带者补硒对 HBV转归的影响。方法 对 HBs Ag携带者 2 0 6 5例随机分为补硒组和对照组 ,连续服药观察 3年。2组随机抽检各 5 0 0例 HBV五项指标。结果 服药前补硒组与对照组无显著性差异 (P >0 .0 5 ) ,服药后 1年 ,补硒组 HBs Ag转阴率 10 .8% ,抗 - HBs阳性率为 5 .6 % ,两组均出现显著性差异 (P <0 .0 0 1) ;同时补硒组 HBs Ag转阴率显著高于对照组6 .4% (P <0 .0 0 5 ) ,抗 - HBs检测率补硒组亦显著高于对照组 1% (P <0 .0 0 1)。结论 补硒对改善HBV感染、促使 HBs Ag转阴与抗 - HBs的产生及预防肝癌的发生具有十分重要的临床意义。

Objective To understand the negative returning effect on HBV markers by adding selenium to carriers. Methods This study investigated 2 065 HBsAg carriers who were divided randomly into two groups, the group of adding selenium and the control. The two groups have been followed up for two years. Results We tested 500 random blood samples from each group for 5 HBV markers: HBsAg,anti HBs, HBeAg, anti HBe, anti HBc. It suggests that there is no difference in HBV markers between the two groups before taking the selenium tablets (P>0 05). After adding selenium for one year, HBsAg turns negative in 10.8% persons of adding selenium group, the anti HBs rate is 5.6%. There is significant difference between the two groups (P<0 001) ;The HBsAg negative returning rate of adding selenium group is significantly higher than that of control (6 4%, P<0 005). The anti HBs rate of adding selenium group is significantly higher than that of control (1%, P<0.001).Conclusions Adding selenium has very important clinical value of improving infecting condition, promoting HBsAg negative returning, stimulating anti HBs, and reducing occurrence of liver cancer.