雌、孕激素受体状态与乳腺癌危险因素的关系

Relationship between steroid receptor status and risk factors for breast cancer

目的 探讨雌、孕激素受体 (ER、PR)状态不同的乳腺癌是否在发病危险因素方面有差异。方法 1996年 3月～ 1998年 1月间在大连医科大学附属一、二院进行了一次病例对照研究。结果 病例间受体状态分析提示在年龄上 ER组间有差别 ;PR组间各因素都没有差异。病例对照间单因素及多因素L ogistic回归分析发现按 ER状态分层 ,唯有 BMI、活产胎数、哺乳时间对 ER(+)及 ER(- )乳腺癌危险性的作用不同 ;按 PR状态分层分析各因素对 PR(+)及 PR(- )乳腺癌的作用是一致的。结论 结果从总体上支持

Objective To determine relationship between steroid receptor status and risk factors for breast cancer. Methods Pair matching case control study was conducted from First and Second Affiliated Hospital of Dalian Medical University in 1996～1998. Results Intercase analysis showed no differences between risk factors and receptor status except for age. The result of case control analysis revealed that only BMI、 number of birth、 duration of breast feeding have some different effects on ER(+) and ER(-) breast cancer, while there was no difference between risk factors and breast cancer by PR status. Conclusions This result tends to support to the hypothesis of the two stage modeling by Moolavkar, et al.