尿脱氧吡啶酚可作为妊娠性骨量减少的敏感生化指标

Urine deoxypyridinoline:a biochemical marker sensitive in predicting gestational low bone mass

目的 探讨尿脱氧吡啶酚排泄率对妊娠性骨量减少的诊断意义。方法 用酶联免疫法测定了 60名孕妇 (妊娠组 )和 30名非孕健康妇女 (对照组 )的尿脱氧吡啶酚浓度 ,同时用苦味酸法测定尿肌酐 ,二者相比求得尿脱氧吡啶酚排泄率 (单位为 nmol/ mmol Cr)。结果 对照组妇女尿脱氧吡啶酚排泄率为 ( 3.60± 1.2 9) nmol/ mmol Cr,妊娠组妇女为 ( 4.63± 1.85 ) nmol/ mmol Cr,与对照组相比差异有显著性 ( P<0 .0 5 )。其中妊娠 0～ 3个月组 ( n=2 0 )尿脱氧吡啶酚排泄率为 ( 3.91± 1.32 ) nmol/ mmol Cr,4～ 6个月组 ( n=2 0 )为 ( 4.35± 1.72 ) nmol/ mmol Cr,7～ 9个月组 ( n=2 0 )为 ( 6.34± 2 .2 8) nmol/ mmolCr,与对照组相比分别为差异无显著性 ( P>0 .0 5 ) ,差异有显著性 ( P<0 .0 5 ) ,差异有非常显著性 ( P<0 .0 1)。跟踪调查显示哺乳期妇女尿脱氧吡啶酚排泄率仍维持较高水平 ( 5 .83± 2 .14 ) nmol/ mmol Cr,P<0 .0 1)。结论 尿脱氧吡啶酚排泄率可作为反映妊娠期和哺乳期骨吸收增加的方便、灵敏、特异的生化指标。

Objective To study diagnostic value of urine deoxypyridinoline to gestational low bone mass.Methods Urine deoxypyridinoline was assayed by ELISA in 60 pregnant women ( gestation group) and 30 healthy non- pregnant women( control group) .Urine creatinine( Cr) in the same samples was measured by 2 ,4,6- trinitrophenol method.Results The urine deoxypyridinoline was ( 3.60± 1.2 9) nmol/ mmol Cr in control group,and ( 4.63± 1.85 ) nmol/ mmol Cr in gestation group;the difference was significant( P<0 .0 5 ) .In pregnantwomen,the urine deoxypyridinoline during the first( n=2 0 ) ,second( n =2 0 ) and third( n=2 0 ) trimesters was ( 3.91± 1.32 ) ,( 4.35± 1.72 ) and ( 6.34± 2 .2 8) nmol/ mmol Cr, respectively;compared to the control group,the differences were not significant ( P>0 .0 5 ) ,significant ( P<0 .0 5 ) ,and very significant ( P<0 .0 1) ,respectively.Follow- up investigation showed that the urine deoxypyridinoline during lactation maintained considerably higher level ( 5 .83± 2 .14 nmol/ mmol Cr,P <0 .0 1) .Conclusions Urine deoxypyridinoline is a convenient biochemical marker sensitive in predict- ing the increase of bone resorption in women during their gestation and lactation.