血尿酸水平与缺血性卒中相关分析

The Relation of Blood Uric Acid and Acute Ischemic Stroke

目的:研究血尿酸水平与缺血性卒中的相关性。方法:选择缺血性卒中患者(病例组)100例和健康体检者(对照组)100例,分别测定空腹血尿酸(UA)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C),并对病例组进行颈部动脉超声检查、NIHSS评分、BI指数计算。比较两组尿酸水平及病例组不同血尿酸水平下UA、TC、TG、LDL-C、HDL-C的指标变化及NIHSS评分、BI指数、颈部血管斑块形成率的差别。结果:病例组和对照组空腹血尿酸升高的例数,分别为46例和17例,分别占46%和17%;血尿酸平均浓度分别为485.96±76.03(μmoL/L)和343.12±61.46(μmoL/L),差异有统计学意义。病例组尿酸结果明显高于对照组,两组比较有显著性差异(P<0.01);病例组UA、TC、TG、LDL-C、HDL-C水平较正常对照组差异有显著意义(P<0.05)。对病例组血尿酸水平,颈部血管超声结果、NIHSS评分、BI指数进行分析。病例组患者血尿酸水平与病情及预后有平行关系,即血尿酸水平高,颈部血管斑块形成率高,病情重,预后差。结论:高尿酸血症(HUA)是缺血性卒中重要的危险因素,是防治缺血性卒中的综合因素之一。

Objective： The relation of blood uric acid and acute ischemic stroke is researched.Methods： We have selected 100 examples of acute ischemic stroke and health people to compare.The fasting serum uric acid（UA）,total cholesterol（TC）,triglyceride（TG）,low density lipoprotein（LDL-C） and high density lipoprotein（HDL-C） are measured.At the same time,the carotid artery ultrasound examination,the NIH Stroke Scale and Barthel index of the case group are calculated.For two groups of Uric acid level with the index changing of UA,TC,TG,LDL-C,HDL-C at the various levels are compared.The difference among the NIH Stroke Scale,Barthel index and formation rate of atheromatous plaque in carotid arteries is analyzed.Results： The quantity of the case group and Control group of fasting serum uric acid,are equal to 46 and 17,respectively.Here the percentages are 46% and 17%.The average consistency of Serum uric acid are 485.96±76.03（μmoL/L） and 343.12±61.46（μmoL/L）.The difference has a statistics.The result of UA in case group is higher than control group.The compression of the two groups have significant difference（P〈0.01）.The UA,TC,TG,LDL-C,HDL-C of case group is more significant than natural group（P 〈 0.05）.For the level of UA in case group,the result of the carotid artery ultrasound,the NIH Stroke Scale and Barthel index are analyzed.The UA level of patients at case group has parallel relationship with patients’ condition and prognosis,namely the level of UA is high,formation rate of atheromatous plaque in carotid arteries is high,patients’ condition is heavy,and prognosis is bad.Conclusions： Hyperuricemia is important dangerous factor of ischemic stroke,and is one of synthesis factors preventing ischemic stroke.