细胞因子与类风湿关节炎的研究进展

Progress of the Studies on Relationships between Cytokines and Rheumatoid Arthritis

类风湿关节炎(RA)是一种慢性、多系统的以关节的炎症损害为主要特点的自身免疫性疾病。其发病过程与多种细胞因子有关,包括TNF-α、IL-1、MMPS、IL-6、IL-17、IL-18等,这些细胞因子在RA的发病进程中起了很重要的作用,可作为治疗RA的新靶点。

Rheumatoid arthritis（RA） is an autoimmune disease characterized by chronic inflammation leading to joint destruction with systemic involvement.The pathogenesis of rheumatoid arthritis are related to many cytokines,such as TNF-α,IL-1,MMPS,IL-6,IL-17,IL-18 and so on.It has been confirmed the cytokine-mediated immunity plays a crucial role in the pathoge-nesis of RA and anti-cytokine therapy has become novel target treatment for RA.