BRCA-1基因与神经干细胞

BRCA-1 and Neural Stem Cells

乳腺癌易感基因(Breast cancer susceptibility gene,Brca-1)是肿瘤抑制基因家族中的一员,它是乳腺癌特异性抑癌基因,1994年Miki等[1]采用定位克隆方法首次将Brca-1分离出来。Brca-1能防止细胞过快地或失去控制地生长和分化,在调节细胞进程、DNA损伤修复、细胞生长与凋亡及转录活化和抑制等多种生物学途径都发挥重要作用,Korhonen等2003年报道Brca-1基因可促进体外培养的大鼠来源的神经干细胞的增殖。

Breast cancer susceptibility gene（BRCA-1）,a member of tumor suppressor gene family,by which breast cancer can be inhibited specificly,was dissociated by Miki et al.through positioning cloning at 1994.It can prevent the over-quick or uncontrolled growth and differentiation.It plays important roles in many fields,Such as regulation of cells process,repareation after DNA damage,growth and apoptosis of cells,activation and inhibitiation of transcription and so on.In 2003,it was reported by Korhonen et al.that the proliferation of vitro cultured neural stem cells of rat can be promoted by BRCA-1.