香丹注射液在急性胰腺炎治疗中的应用

The effect of Xiangdan Injection on acute pancreatitis

目的观察香丹注射液在急性胰腺炎治疗中的应用疗效并探讨其机制。方法118例急性胰腺炎患者随机分为试验组与对照组，均给予常规西医治疗，试验组加用香丹注射液治疗，采用疗效等级、平均住院天数、并发症发生率来评价香丹注射液的治疗效果，同时测定患者的血浆血小板活化因子（PAF）、肿瘤坏死因子α（TNF—α）、超氧化物歧化酶（SOD）和血清钙离子水平。结果试验组与对照组的治疗总有效率和并发症发生率无显著性差异，但试验组患者的痊愈率高于对照组，住院天数短于对照组。试验组的PAF和TNF-α水平显著低于对照组，SOD水平显著高于对照组，钙离子水平无明显差异。结论急性胰腺炎患者应用香丹注射液能改善疗效，其机制与降低血炎症因子水平、提高抗氧化活性有关。

Objective To explore the effect of Xiangdan Injection on acute pancreatitis and its mechanism. Methods 118 patients with acute pancreatitis were randomly divided into two groups. Both groups were treated by routine therapy while Xiangdan Injection was prescribed to the test group. The grade of therapeutic effect, average hospital day and complication incidence were used to evaluate the effect of Xiangdan Injection. The level of PAF, TNF-α, SOD and calcium ion were also detected. Results The efficient and complication had no significant difference between two groups, while the ratio of full recovery of test group was higher than that of contrast group, and the average hospital day of test group was shorter than that of contrast group. The level of PAF, and TNF-α of test group was lower than that of contrast group. The level of SOD of test group was higher than that of contrast group, and the level of calcium ion had no significant difference. Conclusion Xiangdan Injection can improve the effect of treatment for acute pancreatitis and the effect maybe due to its lowering the level of inflammatory factors and enhancing anti-oxidant activity.