苦味酸-氧化羧甲基纤维素酯的制备及其对尿素和肌酐的吸附性能

Preparation of carboxymethyl cellulose picric acid ester and adsorption property for urea and creatinine

以羧甲基纤维素钠为原料,高碘酸钠为选择性氧化剂,在酸性条件下制备氧化的羧甲基纤维素。再将氧化的羧甲基纤维素6位的羧基进行酰化,与苦味酸反应制备复合型靶向口服吸附剂苦味酸-氧化羧甲基纤维素酯。通过XRD、FTIR、元素分析及化学官能团测定(碱熔法测醛基含量)等方法对苦味酸-氧化羧甲基纤维素酯的结构进行表征,结果表明苦味酸-氧化羧甲基纤维素酯已生成;在模拟人体生理介质的条件下,测定苦味酸-氧化羧甲基纤维素酯对尿素和肌酐的吸附性能,对尿素和肌酐的吸附平衡时间分别为10h和6h,醛基含量为75.23%。对尿素和肌酐的饱和吸附容量分别为16.08mg/g和2.10mg/g。尿素在氧化CMC-PA上的吸附等温线均符合Freundich方程,说明主要为化学吸附且吸附指数(1/n)小于2,表明吸附为"优惠吸附"。

Sodium periodate as selective oxidant, oxidized carboxymethylcellulose was prepared from carboxymethyl cellulose under acidic conditions. The carboxyl on C6 of oxidized carboxymethylcellulose was acylated and composite targeted oral adsorbent ester of oxidized carboxymethylcellulose-based picric acid （CMC-PA） was prepared by reaction with it and picric acid.The structure of oxidized CMC-PA was characterized by XRD,FTIR,element analysis and chemical functional determination（alkali fusion method to measure aldehyde content） ,the results showed that oxidized CMC-PA was prepared.The adsorption property of oxidized CMC-PA to urea and creatinine was studied under simulated biological human body conditions,results showed that adsorption amount reached an equilibrium value after ]Oh and 6h respectively, aldehyde content was ＂75.23%.The saturated adsorption capacity to urea and creatinine were 16.08mg/g and 2.i0mg/g, respectively.The adsorption isotherms of urea on oxidized CMC-PA fit well with Freundich equation, indicating that the adsorption was mainly chemical adsorption.The Freundich index（l/n）was less than 2,which implied that the adsorption was preferential process.