我院大肠埃希菌耐药性分析

Analysis of Antimicrobial Resistance of 266 Escherichia Coli

目的了解我院2011年大肠埃希菌对常用抗菌药物的耐药现状及标本分布,为临床治疗提供依据。方法对2011年1月～12月临床科室送培标本分离出的266株大肠埃希菌的耐药情况进行回顾性分析。结果我院分离的266株大肠埃希菌对各类常用抗菌药物均表现为严重耐药,其中环丙沙星的耐药率最高,达83.2%,庆大霉素、头孢唑林钠、头孢呋辛钠和头孢曲松钠耐药率达70%～80%,左氧氟沙星、头孢噻肟钠、氨苄西林/舒巴坦钠的耐药率在60%～70%,仅头孢西丁钠的耐药率低于50%。结论我院分离的大肠埃希菌耐药严重,且呈多重耐药,故临床必须重视合理使用抗菌药物,以减少或延缓多重耐药菌株的产生。

Objective To investigate the distribution and situation of antimicrobial resistance of escherichia coli isolated from our hospital in 2011,sa as to provide reference for antimicrobial treatment.Methods A total of 266 strains of escherichia coli isolated during Jan.2011 and Dec.2011 were retrospectively analyzed according to the source of specimens and drug-resistance.Results The drug resistance to all kinds of antibiotics was strong.The highest resistance rate of escherichia coli was present in ciprofloxacin（83.2%）.In gentamicin,cefazolin,cefuroxime and ceftriaxone,a lower resistance rate of escherichia coli varying from 70% to 80% was confirmed.In levofloxacin,cefotaxime and ampicillin/sulbactam,the resistance rate was between 60% to 70%,and only the resistance rate of Cefoxitin was less than 50%.Conclusion Escherichia coli,isolated from the patients,has shown a high rate of resistance to routine antimicrobial agents,and even has presented multiple antibacterial resistance.So rational use of antimicrobial agents must be emphasized in order to reduce or delay the production of multi-drug resistant strains.