前列腺素光化学前体:(1R,5S)-3-羟基二环[3,1,0]己基-6-基(苯基)甲酮的二维核磁表征
The characterization of the precursor of prostaglandin:(1R,5S)-3-Hydroxy bicyclo [3,1,0] hexan-6-yl(phenyl) methanone by two dimensional NMR
摘要
以二环[3,1,0]己烷为骨架设计前列腺素光化学前体的反应路线,经过10步反应合成了具有NorrishⅡ型光化学特点的光化学反应前体目标产物.通过MS、HPLC、1 H NMR、13C NMR和DEPT 135等手段的表征了该化合物的一维结构,并且利用二维核磁共振技术1 H-1 H COSY、HSQC、HMBC、ROESY和NOE等手段对所合成目标产物的二维结构物进行了测定,确定了目标产物的空间结构.
A reasonable synthetic route was designed based on bicyclo hexane skeleton.Norrish II type photochemical precursor（1R,5S）-3-hydroxyl bicycle hexan-6-yl）（phenyl） methanone target product was successfully synthesized through ten steps.The one-dimensional structure of target product was determined by means of MS、HPLC、1H NMR、13C NMR and DEPT 135.The two-dimensional structure of target product was determined by means of 1H-1H COSY、HSQC、HMBC、ROESY and NOE.
出处
《辽宁师范大学学报（自然科学版）》
CAS
2012年第1期69-72,共4页
Journal of Liaoning Normal University:Natural Science Edition
基金
辽宁省教育厅高校科研项目(2009A426)
辽宁省教育厅创新团队项目(2008T107)
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