喹啉氧基酞菁金属配合物光敏化氧化色氨酸能力的研究

Study on Photosensitive Oxidation Ability of Metallophthalocyanines on Tryptophan

酞菁金属配合物是光动力治疗的新一代光敏剂,其治疗作用的机理以及引起的生物效应一直是人们研究的热点.本文选用色氨酸作为与喹啉氧基酞菁金属配合物作用的靶分子,讨论了配合物的组成结构与其光敏化氧化色氨酸能力的相关性.结果表明,酞菁环内中心金属离子和环周边取代基的组成结构以及取代位置与数目都影响其光敏化氧化色氨酸能力,中心金属离子为闭壳层电子结构、取代基位于α位以及提高取代基数目均有利于提高光敏化氧化活性,同时显示,取代基的组成结构对靶分子有一定选择性,研究结果可为研发该类光敏剂提供依据.

Phthalocyanines are promising photosensitizers for application in PDT. The mechanism of the therapeutic and biological effects induced by them has been the hot topic of research on PDT. Tryptophan was choosed as a target molecule which reacted with metallophthalocyanines substituted with quinolinoxy groups, to discuss the relationship between structure and photosensitive oxidation ability. The results show that photo-oxidizing ability of phthalocyanines was influenced by the central metal ion, the structure of substitutional group, the substituent position and the number of substitutional group. Phthalocyanines with closed-shell electronic structure central metallic ion, rich substituents and substituted in a position, exibit higher photosensitive oxidation ability. This study can offer some guidance for the design of new photosensitizers.