七叶皂苷治疗内痔87例临床观察

Clinical observation on sodium aescinate in the treatment of 87 patients with internal hemorrhoids

目的观察七叶皂苷治疗Ⅰ-Ⅱ期内痔的临床疗效。方法将177例Ⅰ-Ⅱ期内痔患者随机分为治疗组（87例）和对照组（90例），治疗组采用七叶皂苷片治疗，每次2片，每天2次口服。对照组外用痔疮栓剂，每次1枚，每天2次外用。两组均以7d为1个疗程，疗程结束后判定疗效。结果治疗组临床控制43例、显效33例、有效7例、无效4例、总有效率95．4％，对照组分别为23例、22例、28例、17例、81．1％，两组总有效率差异有统计学意义（X2=8．64，P〈0．01）。治疗组便血、肛门坠痛等症状疗效均优于对照组（均P〈0．01），脱垂、痔黏膜充血、痔核大小等症状疗效、总积分差值与对照组比较差异均有统计学意义（均P〈0．05）。结论应用七叶皂苷治疗Ⅰ-Ⅱ期内痔有较好的临床疗效，且临床症状改善率较高。

Objective To observe the clinical effect of sodium aescinate in the treatment of patients with stage Ⅰ-Ⅱ internal hemorrhoids. Methods 177 patients with stage Ⅰ-Ⅱ internal hemorrhoids were randomly divid- ed into two groups, the treated group （ n = 87） and the control group （ n = 90）. Patients in the control group were treated with external hemorrhoids suppositories （1 per time,bid） ,while patients in the treated group took sodium aesci- nate orally（2 per time, Bid）. After the 7-day course of treatment, the efficacy of sodium aescinate was determined. Results There was significant difference between the two groups in the total obvious effective rate and the total effective rate（P 〈 0.01 ）. Compared with the control group, the symptoms of hematochezia and anal pain were more improved in the treated group（P 〈0.01 ）. There was significant difference between the two groups in the hemorrhoidal mucosa, prolapse, the size of hemorrhoids and total score difference （P 〈0. 05 ）. The total obvious effective rate and the total effective rate of the treated group were 87.4% and 95.4%. Conclusion Sodium aescinate had better clinical effect in the treatment of patients with stage Ⅰ-Ⅱ internal hemorrhoids.