卡维地洛治疗慢性心力衰竭并心律失常60例疗效分析

The efficacy evaluation of carvedilol in the treatment of 60 chronic heart failure patients with arrhythmias

目的探讨卡维地洛治疗慢性心力衰竭并心律失常的疗效。方法120例慢性心力衰竭并心律失常患者随机分为治疗组和对照组各60例，对照组给予常规治疗，包括贝那普利、地高辛、呋塞米或氢氯噻嗪、螺内酯等治疗，治疗组在对照组治疗的基础上加用卡维地洛，随访12周，比较两组治疗前后血压、左室射血分数、心律失常缓解情况及疗效。结果治疗组在降低心率、纠正室上性期前收缩、室性期前收缩、室性心动过速及射血分数等明显优于对照组（t=6．018、5．319、7．623、6．194、7．562，P〈0．01）；治疗组显效43例、有效15例、无效1例、死亡1例、总有效率96．7％，对照组分别为24例、14例、17例、5例、63．3％，两组总有效率差异有统计学意义（x2=34．301，P〈0．05）。结论卡维地洛在改善心功能、减少心律失常、降低病死率等方面，疗效肯定。

Objective To investigate the clinical effect of carvedilol in the treatment of chronic heart failure patients with arrhythmia. Methods 120 cases of hospitalized cases of cardiology were randomly divided into treatment and control groups by checking the random number table. The control group was given benazepril hydrochloride combined digoxin cardiac medicine and furosemide or hydrochlorothiazide, spironolactone and other diuretics in the treatment. The treatment group was given carvedilol based on the treatment of the control group. Followed up for 12 weeks, the clinical manifestations, blood pressure and heart rate, left ventricular ejection fraction（EF） and arrhythmias before and after treatment were obsered, and to determine the efficacy. Results The treatment group decreased heart rate, corrected ventricular premature contraction, ventricular contraction and ventricular tachycardia in comparison with the control group with significant differences （ t = 6.018,5.319,7. 623,6.194,7. 562, all P 〈 0. 001 ）, and there was a significantly statistical significance（ P 〈0. 01 ） that the treatment group can increase the ejection fraction compared with the control group. The markedly and total efficiency was more effective in the treatment group than the control group,which was statistically significant（ x2 = 34. 301 ,P 〈0. 05 ）. Conclusion There was a positive effect of carvedilol in improving heart function, reduceing arrhythmias and mortality, and reducing hospitalization rate and other aspects.