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口腔颌面部侵袭性纤维瘤20例临床病理分析

Clinical and pathological analysis of twenty patients with primary desmoid type fibroma arising from the oral and maxillofacial region
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摘要 目的:口腔颌面部原发性侵袭性纤维瘤十分罕见,本文主要分析口腔颌面部原发性侵袭性纤维瘤的发病情况和临床诊疗措施。方法:回顾性分析我院收治的20例口腔颌面部原发性侵袭性纤维瘤患者的临床及病理特点,采用SPSS 10.0软件包对数据进行t检验。结果:本组20例患者中,男12例,女8例,男女比例3∶2;下颌骨是最常见的发病部位;6例发生癌变,局部复发率高达53%;65%患者的血清碱性磷酸酶含量异常增高(P<0.05),提示病变与颌骨吸收关系密切。结论:口腔颌面部原发性侵袭性纤维瘤具有侵袭性生长及复发率高等特点,治疗以手术切除为主,配合术后放疗,血清碱性磷酸酶水平增高可作为评估骨质吸收的潜在标志物。 PURPOSE: Primary desmoids type fibroma arising from the oral and maxillofacial region is uncommon.The purpose of this study was to analyze the clinicoepidemiological characteristics of this rare disease.METHODS: Epidemiological and clinicopathological data on 20 patients were reviewed from the hospital records and analyzed accordingly.The data were processed with SPSS10.0 software package.RESULTS: Twelve males and 8 females with a ratio of 3∶2 were involved.The mandible was the most common site of presentation.Suspected malignant change was found in 6 cases and an extremely high recurrence rate was also found in up to 53%.Abnormally high blood levels of alkaline phosphatase were found in 65% of patients,which had a close relation with bone resorption.CONCLUSIONS: Desmoids type fibroma arising from the oral and maxillofacial region hold the character of local invasion and regional recurrence;surgery is chosen as the most effective treatment combined with postoperative radiotherapy;elevated serum alkaline phosphatase levels may be used as an indicator for bone resorption.
出处 《中国口腔颌面外科杂志》 CAS 2012年第2期118-122,共5页 China Journal of Oral and Maxillofacial Surgery
基金 上海市自然科学基金(11ZR1420600) 上海市重点学科建设项目(S30206)~~
关键词 侵袭性纤维瘤 碱性磷酸酶 骨吸收 恶变 Desmoids type fibroma Alkaline phosphatase Bone resorption Malignant transformation
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