口腔颌面部炎症性肌纤维母细胞瘤8例临床分析

Clinical analysis of 8 inflammatory myofibroblastic tumours in oral and maxillofacial region

目的:探讨炎症性肌纤维母细胞瘤(IMT)在口腔颌面部的临床表现及治疗方法。方法:回顾总结2007—2011年期间诊治的8例颌面部IMT患者,分析其临床资料及治疗方法。结果:口腔颌面部炎症性肌纤维母细胞瘤肉眼观均为实性肿物,呈浸润性生长,与周围软组织黏连,无明显包膜。肿瘤镜检主要有梭形细胞型和黏液血管型2种组织学形态。除1例术后失访外,其余患者随访1～3a,情况稳定,未见局部复发或远处转移。结论:IMT是一种少见的间叶性肿瘤,多见于儿童和青壮年,罕见于头颈部,具有局部侵袭性和复发等低度恶性或交界瘤特点,远处转移少见;手术切除是口腔颌面部IMT首选的治疗方法。

PURPOSE：To investigate the clinical characteristics and treatment of inflammatory myofibroblastic tumor in oral and maxillofacial region.METHODS：The clinical protocols and treatment outcomes of 8 patients treated during 2007 to 2011 were analyzed retrospectively.RESULTS： IMT in oral and maxillofacial region appeared as a mass without margins.Two basic histologic patterns were observed： compact spindle cells with intermingled inflammatory cells（lymphocytes,plasma cells,and eosinophils）resembling fibrous histiocytoma;myxoid,vascular,and inflammatory areas resembling nodular fasciitis.Patients were followed up for 1-3 years except one lost follow-up,and has no tumor recurrence or distant metastases.CONCLUSION： Inflammatory myofibroblastic tumor is an uncommon lesion,preferentially occurring in children and young adults.IMT is rarely encountered in the head and neck,and has a variable natural course from benign with spontaneous regression to mimicking malignant tumors.Complete surgical resection is the treatment of first choice.