微小RNA对干细胞的调控
摘要
miRNA是一类小分子“非编码”RNA，主要通过对基因转录后的负性调控抑制基因表达。miRNA在干细胞增殖、“多能性”保持、分化中均有作用，其通过调控一些下游基因的表达及一些转录因子的相互调节影响个体的生长、发育以及肿瘤的形成和发展。本文对miRNA的发生和作用机制，其在胚胎干细胞、成体干细胞及肿瘤干细胞中的表达和作用做一综述。
出处
《国际耳鼻咽喉头颈外科杂志》
2012年第2期111-115,共5页
International Journal of Otolaryngology-Head and Neck Surgery
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