Poly(N-isopropylacrylamide)-based Vertically Sandwich-typed Hydrogel with Fast Temperature-response Speed and Its Controlled-release Characteristics

Poly(N-isopropylacrylamide)-based Vertically Sandwich-typed Hydrogel with Fast Temperature-response Speed and Its Controlled-release Characteristics

下载PDF

导出

摘要 A novel poly（N-isopropylacrylamide）-based sandwich-typed hydrogel, which was featured with both ends of linear poly（N-isopropylaerylamide）（PNIPAM） chains being grafted onto cross-linked PNIPAM chains, was successfully prepared in a three-step process by a method of sequential synthesis. The proposed hydrogel displays faster and hydration/dehydration dynamic response to temperature cycling owing to linear PNIPAM chains to form big-pore structure. This work may lead to high attraction for targeting drug delivery systems, polymeric pump, sensors and so on. A novel poly（N-isopropylacrylamide）-based sandwich-typed hydrogel, which was featured with both ends of linear poly（N-isopropylaerylamide）（PNIPAM） chains being grafted onto cross-linked PNIPAM chains, was successfully prepared in a three-step process by a method of sequential synthesis. The proposed hydrogel displays faster and hydration/dehydration dynamic response to temperature cycling owing to linear PNIPAM chains to form big-pore structure. This work may lead to high attraction for targeting drug delivery systems, polymeric pump, sensors and so on.

作者卢程肖新才

机构地区 School of Hospital School of Pharmacy

出处《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS 2012年第2期280-284,共5页 武汉理工大学学报（材料科学英文版）

基金 Funded by the National Natural Science Foundation of China (20976202) the Natural Science Foundation of Hubei Province (2009CDB161)

关键词 sandwich-typed hydrogels microstructure poly（N-isopropylacrylamide） gels sandwich-typed hydrogels microstructure poly（N-isopropylacrylamide） gels

分类号 O633.22 [理学—高分子化学]

引文网络
相关文献

参考文献1

1高玉香.Poly(N-isopropylacrylamide), Poly(methacrylic acid) and Their Copolymers for Oral Colon-specific Drug Delivery[J].Journal of Wuhan University of Technology(Materials Science),2009,24(4):571-574. 被引量：3

二级参考文献11

1V. R. Sinha,Rachna Kumria.Colonic Drug Delivery: Prodrug Approach[J].Pharmaceutical Research.2001(5)
2Maroni A,Curto. M D D,Serratoni M, et al.Feasibility, Stability and Release Performance of a Time-dependent In- sulin Delivery System Intended for Oral Colon Release[].European Journal of Pharmaceutics and Biopharmaceutics.2009
3Gazzaniga A,Maroni A,Sangalli ME, et al.Time-controlled Oral Delivery Systems for Colon Targeting[].Expert Opin Drug Deliv.2006
4Yihua Yin,Yajiang Yang,Huibi Xu.Hydrogels for Co- lon-Specific Drug Delivery: Swelling Kinetics and Mecha- nism of Degradation in vitro[].Journal of Polymer Science Part B: Polymer Physics.2001
5Koussathana M,Lianos P,Staikos G.Investigation of Hy- drophobic Interactions in Dilute Aqueous Solutions of Hy- drogen-Bonding Interpolymer Complexes by Steady-State and Time-Resolved Fluorescence Measurements[].Mac- romolecules.1997
6Malik,D. K.,Baboota,S.,Ahuja,A.,Hasan,S.,Ali,J.Recent advances in protein and peptide drug delivery systems[].Current Drug Delivery.2007
7Y.W. Lin,Q. Chen,H.B. Luo.Preparation and characterization of N-(2-carboxybenzyl)chitosan as a potential pH-sensitive hydrogel for drug delivery[].Carbohydrate Research.2007
8Yin, Y. H,Yang, Y. J.,Xu, H. B.Swelling Behavior of Hydrogels for Colon-Site Drug Delivery[].Journal of Applied Polymer Science.2002
9Mahkam M.New pH-sensitive glycopolymers for colon-specific drug delivery[].Drug Delivery.2007
10Musial W,Kubis A.Biodegradable polymers for colon-specific drug delivery[].Polim Med.2005

共引文献2

1LI Ying,XIAO Xincai.Laterally Sandwich-typed Hydrogel Columns with Liner Poly(N-isopropylacrylamide) Layer:Preparation, Swelling/deswelling Kinetics and Drug Delivery Characteristics[J].Journal of Wuhan University of Technology(Materials Science),2012,27(1):115-119.
2黄雷,王小涛,XIE Xun,XIE Weihong,LI Xuefeng,GONG Xinghou,LONG Shijun,GUO Huiling,刘最芳.Synthesis and DNA Adsorption of Poly(2-Vinyl-4,6-Diamino-1,3,5-Triazine)Coated Polystyrene Microspheres[J].Journal of Wuhan University of Technology(Materials Science),2018,33(4):999-1006. 被引量：3

1于泓,李睿姝.整体柱离子对色谱快速分析高氯酸盐[J].分析化学,2008,36(6):835-838. 被引量：6
2BI Li-hua,LIU Jing-hua,WANG En-bo,HUANG Ru-dan,YU Yong-zhang,WU Ping-song.Syntheses and Liquid Crystal Properties of New Rare Earth Sandwich Type Heteropoly Compounds[J].Chemical Research in Chinese Universities,1999,15(4):364-366. 被引量：2
3朱文祥,苟宝迪,张永安,李言,陈学安.Synthesis and Structural Characterization of Adduct [La(NO_3)_3·4H_2O]·2(BQEB)[J].Journal of Rare Earths,2001,19(1):1-5.
4Yayun He,Longhua Ding,Bin Su.Vertically ordered silica mesochannels as preconcentration materials for the electrochemical detection of methylene blue[J].Science China Chemistry,2015,58(10):1593-1599.
5黄小融,郑家贵,蔡亚平,武莉莉,李卫,黎兵,鄢强.串联电阻对CdS/CdTe太阳电池稳定性的影响[J].四川师范大学学报（自然科学版）,2004,27(5):513-515.
6李睿姝,于泓,高微,杨灵.硅胶整体柱离子对色谱快速分析碘离子[J].分析试验室,2010,29(3):85-88. 被引量：8
7朱国斌,李洁,杜启云,王利生,胡小平,严纯华,易涛,李标国.Transport　Behaviour　of　La^（3＋）　with　Hollow　Fiber　Sandwich　Liquid　Membrane　Extraction　System[J].Journal of Rare Earths,1995,13(4):252-256.
8LI,Yong WANG,Gui-Jun Department of Chemistry,Tsinghua University,Beijing 100084.ESR study on some copper(Ⅱ)complexes of bis(4'-benzo-15-crown-5)[J].Chinese Journal of Chemistry,1992,10(4):304-308.
9WANG En-ju CHEN Guang-ying HAN Chang-ri.Crystal Structure of a Novel Sandwich Inclusion Complex of β-Cyclodextrin with α-Naphthylacetic Acid[J].Chemical Research in Chinese Universities,2011,27(5):730-733.
10Wang Zhizhong, Shen Erzhong and Wang Liqun (Institute of Theoretical Chemistry, Jilin University).Electronic Structures of Mono-and Bi-nuclear Benzene-Transition Metal Sandwich Complexes[J].Chemical Research in Chinese Universities,1989,5(3):255-260.

Journal of Wuhan University of Technology(Materials Science)

2012年第2期

浏览历史

内容加载中请稍等...

Poly(N-isopropylacrylamide)-based Vertically Sandwich-typed Hydrogel with Fast Temperature-response Speed and Its Controlled-release Characteristics

参考文献1

二级参考文献11

共引文献2

相关作者

相关机构

相关主题

浏览历史