西酞普兰并奥氮平对更年期抑郁症疗效观察

A comparative study of citalopram angument with olanzapine in the treatment of climacteric depression

目的探讨西酞普兰合并奥氮平对更年期抑郁症的疗效。方法回顾性将2008年8月～2011年5月本院收治的更年期抑郁症患者64例,随机分为实验组和对照组,实验组用西酞普兰合并奥氮平治疗,对照组单用西酞普兰治疗,共治疗6周,采用汉密尔顿抑郁量表(HAMD)、改良的更年期症状评分表Kupperman(KMI)及副反应量表(Treatment Emergent Symptom Scale,TESS)评定疗效。结果治疗后,两组总治疗效果(显效+有效)差异有统计学意义(χ2=30.64,P<0.05);两组HAMD和KMI评分较治疗前均有显著性降低(P<0.05);6周后研究组的HAMD评分低于实验组,且差异具有统计学意义(P<0.05)。两组不良反应均较少。结论西酞普兰合并奥氮平能更加有效地控制患者症状,值得推广。

Objective To explore the efficacy of citalopram angument with olanzapine in the treatment of climacteric de- pression. Methods A total of 64 patients with climacteric depression were randomly divided into study group with citalo pram combined with olanzapine and control group with citalopram for 12 weeks of treatment. They were assessed and anal ysed eontrastively using Hamilton Depression Scale （HAMD）, Kupperman （KMI） and clinical efficacy and Treatment Emer gent Symptom Scale （TESS） for side effects. Results After treatment, the difference of total effect between two groups was significant （X2 = 30.64,P 〈 0.05）; the scores of HAMD and KMI in two groups were both significantly lower than those be fore treatment. In the 6th weekend of treatment, the scores of HAMD and KMI in study group were significantly lower than those in control group. No severe side effects were found in two groups. Conclusion Citalopram augmented with olanzapine is more efficient to control the svmntoms. It is worlh of snreading.