1Serrano M,Hannon GJ,Beach D.A new regulatorymotif in cellcycle control causing specific inhibition ofcyclin D/CDK4[J].Nature,1993,366(6356):704-707.
2Kamb A,Gruis NA,Weaver-Feldhaus J,et al.A cellcycle regulator potentially inbolbed in genesis of manytumor types[J].Science,1994,264(5157):436-440.
3Khoo CM,Carrasco DR,Bosenberg MW,et al.Ink4a/Arf tumor suppressor does not modulate the degener-ative conditions or tumor spectrum of the telomerasedeficient mouse[J].Proc Natl Acad Sci USA,2007,104(10):3931-3936.
4Nemtsova MV,Zemliakova VV,Kuznetsova EV.Cor-relation of p16/INK4agene damages and protein ex-pression in the tumor tissue of sporadic breast cancer[J].Arkh Patol,2008,70(4):6-9.
5Gupta N,Srinivasan R,Rajwanshi A.Functional bio-markers in cervical precancer:An overviewr[J].DiagnCytopathol,2010,38(8):618-623.
6O′Neill CJ,McCluggage WG.p16expression in the fe-male genital tract and its value in diagnosis[J].AdvAnat Pathol,2006,13(1):8-15.
7Mulvany NJ,Wilson SM.Diagnostic utility ofp16INK4A:a reappraisal of its use in cerbical biopsies[J].Pathology,2008,40(4):335-334.
8Jedpiyawongse A,Homcha-em P,Karalak A,et al.Im-munohistochemical overexpression of p16protein as-sociated with cervical cancer in Thailand[J].Asian PacJ Cancer Prev,2008,9(4):625-630.
9Horn LC,Reichert A,Oster A,et al.Immunostainingfor p16INK4Aused as aconjunctive tool improves in-terobserver aggrement of the histologic diagnosis ofcervical intraepithelial neoplasia[J].Am J SurgPathol,2008,32(4):502-512.
10Meyer JL,Hanlon DW,Andersen BT,et al.Evalua-tion of p16INK4A espression in ThinPrep cervicalspecimens with the CINtec p16INK4aassay:correla-tion with biopsy follow-up results[J].Cancer,2007,111(2):83-92.