1Benarroch,Eduardo E.Circumventricular organs Receptive and home-ostatic functions and clinical implications[J].Neurology,2011,77(12):1198-1204.
2Cotrell GT,Ferguson AV.Sensory circumventricular organs:centralroles in integrated autonomic regulation[J].Regul Pept,2004,117:11-23.
3Jean-Stephane Jolly,Joana Osorio,Alessandro Alumni,et al.Win-dows of the brain:Towards a developmental biology of circumventricu-lar and other neurohemal organs[J].Seminars in Cell&Developmen-tal Biology.2007,18:512-524.
4Rivest S.Molecular insights on the cerebral innate immune system[J].Brain Behav Immun 2003,17:13-19.
5张朝佑.人体解剖学[M].第3版.北京:人民卫生出版社,2009.418-421.
6Engelhardt B.The blood-central nervous system barriers activelycontrol immune cell entry into the central nervous system[J].CurrPharmaceutical Design,2008,14:1555-1565.
7Chakravarty S,Herkenham M.Toll-like receptor 4 on nonhemato-poietic cells sustains CNS inflammation during endotoxemia,inde-pendent of systemic cytokines[J].Neurosci,2005,25:1788-1796.
3Petry KG, Boulleren AI, Pousset F, et al. Experimental allergic encephalomyelitis animal models for analyzing features of multiple sclerosis. Pathol Biol ( Paris), 2000, 48 : 48-53.
4Nguyen KB, McCombe PA, Pender MP. Macrophage apoptosis in the central nervous system in experimental autoimmune encephalomyelitis. J Autoimmun, 1994, 7: 145-152.
5Pender MP. Activation-induced apoptosis of autoreactive and alloreactive T lymphocytes in the target organ as a major mechanism of tolerance . Immunol Cell Biol, 1999, 77 : 216-223.
6Suvannavejh GC, Dal Canto MC, Matis LA, et al. Fas-mediated apoptosis in clinical remissions of relapsing experimental autoimmune encephalomyelitis. J Clin Invest, 2000, 105: 223-231.
7Tabi Z, Mcombe PA, Pender MP. Antigen-specific down-regulation of myelin basic protein-reactive T ceils during spontaneous recovery from experimental autoimmune encephalomyelitis: further evidence of apoptotic deletion of autoreactive T ceils in the central nervous system. Int Immunol, 1995, 7 : 967-973.
8Okuda Y, Bernard CC, Fujimura H, et al. Fas has a crucial role in the progression of experimental autoimmune encephalomyelitis. Mol Immunol, 1998, 35 : 317-326.
9Quan N, Stern EL, Whiteside MB, et al. Induction of pro-inflammatory cytokine mRNAs in the brain after peripheral injection of subseptic doses of lipopolysaccharide in the rat. J Neuroimmunol, 1999,93 : 72 -80.
10White CA, McCombe PA, Pender MP. The roles of Fas, Fas ligand and Bcl-2 in T cell apoptosis in the central nervous system in experimentral autoimmune encephalomyelitis. J Neuroimmunol, 1998, 82 : 47-55.
3Germanh A, Montalbano G, Guerrera MC, et al. Develop-mental changes in the expression of sox2 in the zebrafish brain[J]. Mierose Res Teeh,2919,74(4) :347-354.
4Ellis P, Fagan BM, Magness ST, et al. SOX2, a persistent marker for multipotential neural stem cells derived from embryonic stem cells, the embryo or the adult [J]. Dev Neurosci, 2004,26 ( 2 - 4) : 148 - 165.
5Foret A, Quertainmont R, Botman O, et al. Stem ceils in the adult rat spinal cord:plasticity after injury and tread- mill training exercise[J]. J Neurochem, 2010,112(8) : 762 -772.
6Hendrickson ML,Rao AJ,Demerdash ON, et al. Expres- sion of nestin by neural ceils in the adult rat and human brain[J]. PloS One,2011,6(4) :e18535.
7Ramchandra R, Hood SG,Watson AM,et al. Central an- giotensin type 1 receptor blockade decreases cardiac but not renal sympathetic nerve activity in heart failure[J]. Hypertension, 2012,59 (3) : 634- 641.
8Mortazavi MM , Tubbs RS, Harmon D, et al. Chronic em- esis due to compression of the area postrema by the pos- terior inferior cerebellar artery: resolution following mi- crovascular decompression [ J ]. J Neurosurg Pediatr, 2010,6 (6) : 583 - 585.
9Fauquier T, Rizzoti K, Dattani M, et al. SOX2 - express- ing progenitor cells generate all of the major cell types in the adult mouse pituitary gland[J]. Proc Natl Aead Sci U S A,2008,105(8):2907-2912.
10Kelherman D, Rizzoti K, Avilion A, et al. Mutations within Sox2/SOX2 are associated with abnormalities in the hypothalamopituitary gonadal axis in mice and hu- mans[J]. J Clin Invest,2006,116(9) :2442-2455.