多囊卵巢综合征患者血清Ghrelin水平测定及其意义

Clinical meaning of detectting serum ghrelin levels in polycystic ovary syndrome

目的探讨血清生长素(Ghrelin)与多囊卵巢综合征(PCOS)的关系。方法选择PCOS患者35例(P-COS组)及正常体检者33例(对照组),两组服75 g葡萄糖粉后,分别检测空腹与服糖1、2 h血脂,基础血激素(雌激素、孕激素、卵泡刺激素、黄体生成素、泌乳素、睾酮、雄烯二酮)及Ghrelin水平,计算BMI、腰臀比(WHR)、胰岛素抵抗指数及敏感指数。结果 PCOS组BMI、TG、HDL、胰岛素抵抗指数、空腹胰岛素、Ghrelin、睾酮及雄烯二酮在空腹与服糖1、2 h均低于对照组(P<0.05或<0.01)。相关分析显示,血清Ghrelin与BMI、WHR、雄激素、雄烯二酮、空腹血糖呈负相关(r分别为-0.504、-0.336、-0.440、-0.432、-0.414,P均<0.05),与HDL呈正相关(r=0.357,P<0.05)。结论血清Ghrelin可能在PCOS的病理生理过程中发挥作用。

Objectives To study the relationship between serum ghrelin and polycystic ovary syndrom(PCOS).Methods 35 patients diagnosed PCOS were recruited,33 women were voluntary selected as non-PCOS group at the same time.After oral glucose tolerance test(OGTT),insulin serum lipid,based serum hormones of patients were measured.The body mass index(BMI),waist-hip ratio(WHR),insulin resistance index(IR) and insulin sensitivity index(ISI) were caculated.Results The serum ghrelin levers,BMI,FINS,1 hour and 2 hours insulin results,testosterone and androstendione,triglyceride and high-density lipoprotein and insulin resistant index in PCOS group were significantly decreased,compaired with normal group(P<0.05 or <0.01).The serum ghrelin levers was negatively correlated with BMI,WHR,testosterone,androstendione and FPG(r=-0.504、-0.336、-0.440、-0.432、-0.414,all P<0.05),and positively correlated with HDL(r=0.357,P<0.05).Conclusions Ghrelin could play a role in pathophysiology of PCOS.