江苏省肿瘤高发地区肝癌影响因素病例对照研究

A case-control study on risk factors of liver cancer in high-risk area of Jiangsu Province

目的探讨江苏省恶性肿瘤高发区肝癌发病的影响因素及其可能存在的交互作用。方法在肿瘤高发区大丰市进行以自然人群为基础1∶1匹配的肝癌病例对照研究。采用单因素及多因素条件Logistic回归方法,对肝癌可能的影响因素以及吸烟与饮酒、吸烟与饮茶、饮茶与饮酒之间的交互作用分别进行分析。结果单因素条件Logistic回归分析发现,癌症家族史、肝炎家族史、肝炎史、吸烟及被动吸烟等是肝癌发病的危险因素,相应OR值分别为1.512(1.208～1.892)、2.015(1.497～2.713)、4.649(3.259～6.631)、1.367(1.068～1.750)和1.360(1.080～1.713);而饮绿茶、性格开朗、粮食储存时间较长则是肝癌发病的保护因素,相应OR值分别为0.711(0.539～0.937)、0.237(0.142～0.396)和0.633(0.422～0.951)。多因素条件Logistic回归分析发现:癌症家族史、肝炎家族史、肝炎史、吸烟和被动吸烟等是肝癌发病的危险因素,相应OR值分别1.427(1.097～1.857)、1.695(1.199～2.398)、4.822(3.261～7.131)、1.477(1.083～2.015)和1.346(1.019～1.778);而饮绿茶、性格开朗、粮食储存时间较长则是肝癌发病的保护因素,相应OR值分别为0.611(0.437～0.854)、0.251(0.143～0.442)和0.517(0.322～0.831)。结论癌症家族史、吸烟、被动吸烟、肝炎史和肝炎家族史是大丰市肝癌发病的危险因素;饮绿茶、性格开朗和粮食储存时间较长是保护因素。

Objective To study the risk factors of liver cancer in highrisk area of Jiangsu Province. Methods A popula tion based casecontrol study was conducted in Dafeng County. Cases and controls were individually matched and informa tion was collected using standardized questionnaire. Univariate and multivariate conditional logistic regression were applied in data analysis. The interaction analyses were used between smoking and alcohol drinking, smoking and tea drinking, alcohol and tea drinking respectively. Results Family history of cancer, family history of hepatitis, history of hepatitis, smoking, passive smoking were found to be risk factors of liver cancer in Dafeng, the odds ratios （OR） and 95% confidence intervals （CI） were 1. 512 （1. 208-1. 892）, 2. 015 （1. 497-2. 713）, 4. 649 （3. 259-6. 631） and 1. 367 （1. 080-1. 713） respectively. However, green tea drinking, open character, longterm storage of cereal were protective factors of liver cancer, OR and 95% CI were 0. 771 （0. 539-0. 937）, 0. 237 （0. 142-0. 396） and 0. 633 （0. 422-0. 951） respectively. The same results were found in multivariate conditional logistic regression. Conclusion Family histories of cancer, smoking, passive smoking, histo ry of hepatitis, family history of hepatitis were risk factors of liver cancer in Dafeng County. Whereas green tea drinking, open character and longterm storage of cereal were protective factors.