前列腺特异性抗原检测在前列腺疾病中的诊断价值

目的 了解前列腺特异性抗原（PSA）检测对前列腺疾病诊断的临床应用价值.方法 采用雅培i2000SR化学发光免疫检测,分别测定其tPSA、fPSA,计算fPSA/tPSA的比值,从而找出本地区中老年男性血清中tPSA检测值在4～10ng/ml之间的前列腺增生和前列腺癌患者fPSA/tPSA比值的临界值,为临床诊断前列腺癌提供依据.结果 前列腺癌与前列腺增生相比fPSA/tPSA的比值明显减低,差异有统计学意义（P〈0.01）.结论 本地区中老年男性前列腺癌患者fPSA/tPSA比值以〈0.15作为fPSA/tPSA临界值,为前列腺癌早期发现、诊断、疗效监测及预后提供可靠的依据.

Objective To study the clinical significance of PSA （ prostate - specific antigen） testing for prostate diseases. Methods The values of tPSA and fPSA were measured by using the ARCHITECT i2000SR electrochemiluminescenee immunoassay detector and the ratio of fPSA/tPSA was calculated. Then we chose benign prostatic hyperplasia and prostate cancer patients whose tPSA was among 4 - 10 ng/ml, and found out their threshold of fPSA/tPSA. Results The fPSA /tPSA value of patients with prostate cancer was lower significantly than with benign prostatic hyperplasia, and this difference had great significance in the diagnosis（ P 〈 0. 01 ）. Conclusion Rotio of fPSA/tPSA is regarded 〈 0. 15 as the threshold of prostate cancer when using the electrochemiluminescence immunoassay kit in the detections. This approach provided a reliable basis for early detecting, diagnosing, therapeutic effect monitoring and prognosis of prostate cancer.