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FISH在罗伯逊易位携带者胚胎植入前遗传学诊断中的应用

The Clinical Application of Fluorescence in Situ Hybridization for Preimplantation Genetic Diagnosis of Robertsonian Translocation Carriers
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摘要 胚胎植入前遗传学诊断(PGD)是辅助生殖技术中的一种重要手段,染色体异常的诊断是植入前遗传学诊断的一个重要部分。利用荧光原位杂交(FISH)技术对罗伯逊易位携带者体外受精的胚胎行植入前遗传学诊断,可解决生育问题、减少遗传风险,达到优生目的。综述荧光原位杂交技术及近年来该技术在罗伯逊易位携带者胚胎植入前遗传学诊断中的应用。 Preimplantation genetic diagnosis （PGD） is an important technology of the assisted reproductive technology （ART）. The diagnosis of chromosomal abnormality is an important part of PGD. For the in vitro fertilization embryos of Robertsonian translocation carriers, fluorescence in situ hybridization （FISH） as a PGD technology can be used to solve the fertility problem, to reduce genetic risk and achieve the eugenic purposes. This review summarized current knowledge of FISH and its application in PGD of the Robertsonian translocation carriers.
作者 鲁琳琳 白晓红
机构地区 天津医科大学总医院生殖医学中心
出处 《国际生殖健康／计划生育杂志》 CAS 2012年第2期115-118,共4页 Journal of International Reproductive Health/Family Planning
关键词 原位杂交 荧光 易位 遗传 胚胎植入 植入前诊断 生殖技术 辅助 In situ hybridization, fluorescence Translocation, genetic Embryo implantation Preimplantation diagnosis Reproductive techniques,assisted
分类号 R714.8 [医药卫生—妇产科学]
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参考文献20

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国际生殖健康／计划生育杂志
2012年 第2期

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