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SDF-1/CXCR4在神经发生中的作用 被引量：2

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摘要 间质细胞源性细胞因子-1(stromal cell-derived factor-1,SDF-1)是骨髓间质细胞系产生的一种CXC类趋化蛋白,其不仅对免疫细胞具有趋化吸引作用,对中枢神经系统(CNS)也起到重要的作用。CXCR4为SDF-1的特异性受体。SDF-1/CXCR4在发育中和成熟的CNS中均有表达,并通过促进神经前体细胞增殖、分化和移行,调节GABA能神经元、协助神经环路形成而对成年神经发生发挥作用。缺血性脑卒中时,SDF-1水平升高,并通过CXCR4促进新生神经细胞向受损区域迁移和定位,介导损伤后的神经功能修复。
作者 崔黎黎 赵传胜 赵珊珊
机构地区 中国医科大学附属第一医院神经内科
出处 《中国神经免疫学和神经病学杂志》 CAS 北大核心 2012年第2期142-145,共4页 Chinese Journal of Neuroimmunology and Neurology
基金 国家自然科学基金面上项目资助(30872736 30500611)
关键词 间质细胞源性细胞因子-1 CXCR4 神经发生 缺血性脑卒中
分类号 R329.1 [医药卫生—人体解剖和组织胚胎学]
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参考文献23

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同被引文献19

  • 1Kusumoto D, Fukuda K. The role of angiogenetic factors in the pathogenesis and the progression of cardiac valve dis- ease[J]. Clin Calcium,2013,23(4) : 481-488.
  • 2Boyne P, Dunning K, Carl DP, et al. High-intensity inter- val training in stroke rehabilitation [ J ]. Top Stroke Reha- bil,2013,20(4) :317-330.
  • 3Li M, Chang C J, Lathia JD, et al. Chemokine receptor CX- CR4 signaling modulates the growth factor-induced cell cycle of self-renewing and multipotent neural progenitor cells[J]. Glia,2011,59(1) : 108-118.
  • 4Leu S, Lin YC, Yuen CM, et al. Adipose-derived mesen- chymal stem cells markedly attenuate brain infarct size and improve neurological function in rats [ J ]. J Transl Med,2010.8( 1 ) :63.
  • 5Noda M,Omatsu Y,Sugiyama T,et al.SDF-1-CXCR4 chemokine signaling is essential for NK-cell development in adult mice.Blood.2011;117(2):451-458.
  • 6Huber BC,Brunner S,Segeth A,et al.Parathyroid hormone is a DPP-IV inhibitor and increases SDF-1-driven homing of CXCR4(+)stem cells into the ischaemic heart.Cardiovasc Res.2011;90(3):529-537.
  • 7Bellmann-Sickert K,Beck-Sickinger AG.Palmitoylated SDF 1αshows increased resistance against proteolytic degradation in liver homogenates.Chem Med Chem.2011;6(1):193-200.
  • 8Gouwy M,Struyf S,Berghmans N,et al.CXCR4 and CCR5 ligands cooperate in monocyte and lymphocyte migration and in inhibition of dual-tropic(R5/X4)HIV-1 infection.Eur J Immunol.2011;41(4):963-973.
  • 9Berger O,Li G,Han SM,et al.Expression of SDF-1 and CXCR4 during reorganization of the postnatal dentate gyrus.Dev Neurosci.2007;29(1-2):48-58.
  • 10Zhang PZ,He Y,Jiang XW,et al.Up-regulation of stromal cell-derived factor-1 enhances migration of transplanted neural stem cells to injury region following degeneration of spiral ganglion neurons in the adult rat inner ear.Neurosci Lett.2013,8(534):101-106.

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中国神经免疫学和神经病学杂志
2012年 第2期

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